Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries

Despite efforts to reduce the global burden of childhood diarrhoea, 50% of all cases globally occur in children under five years in Low–Income and Middle- Income Countries (LMICs) and knowledge gaps remain regarding the aetiological diagnosis, introduction of diarrhoeal vaccines, and the role of env...

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Autores principales:	Karen H. Keddy, Senjuti Saha, Iruka N. Okeke, John Bosco Kalule, Farah Naz Qamar, Samuel Kariuki
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	childhood diarrhoea infectious diarrhoea gastroenteritis biomarkers proteomics vaccines Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8e658ac362384d11bcbd0a5291b91be9
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spelling	oai:doaj.org-article:8e658ac362384d11bcbd0a5291b91be92021-11-04T04:32:40ZBig data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries2352-396410.1016/j.ebiom.2021.103668https://doaj.org/article/8e658ac362384d11bcbd0a5291b91be92021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S235239642100462Xhttps://doaj.org/toc/2352-3964Despite efforts to reduce the global burden of childhood diarrhoea, 50% of all cases globally occur in children under five years in Low–Income and Middle- Income Countries (LMICs) and knowledge gaps remain regarding the aetiological diagnosis, introduction of diarrhoeal vaccines, and the role of environmental enteric dysfunction and severe acute malnutrition. Biomarkers may assist in understanding disease processes, from diagnostics, to management of childhood diarrhoea and the sequelae to vaccine development. Proteomics has the potential to assist in the identification of new biomarkers to understand the processes in the development of childhood diarrhoea and to aid in developing new vaccines. Centralised repositories that enable mining of large data sets to better characterise risk factors, the proteome of both the patient and the different diarrhoeal pathogens, and the environment, could inform patient management and vaccine development, providing a systems biological approach to address the burden of childhood diarrhoea in LMICs.Karen H. KeddySenjuti SahaIruka N. OkekeJohn Bosco KaluleFarah Naz QamarSamuel KariukiElsevierarticlechildhood diarrhoeainfectious diarrhoeagastroenteritisbiomarkersproteomicsvaccinesMedicineRMedicine (General)R5-920ENEBioMedicine, Vol 73, Iss , Pp 103668- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	childhood diarrhoea infectious diarrhoea gastroenteritis biomarkers proteomics vaccines Medicine R Medicine (General) R5-920
spellingShingle	childhood diarrhoea infectious diarrhoea gastroenteritis biomarkers proteomics vaccines Medicine R Medicine (General) R5-920 Karen H. Keddy Senjuti Saha Iruka N. Okeke John Bosco Kalule Farah Naz Qamar Samuel Kariuki Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries
description	Despite efforts to reduce the global burden of childhood diarrhoea, 50% of all cases globally occur in children under five years in Low–Income and Middle- Income Countries (LMICs) and knowledge gaps remain regarding the aetiological diagnosis, introduction of diarrhoeal vaccines, and the role of environmental enteric dysfunction and severe acute malnutrition. Biomarkers may assist in understanding disease processes, from diagnostics, to management of childhood diarrhoea and the sequelae to vaccine development. Proteomics has the potential to assist in the identification of new biomarkers to understand the processes in the development of childhood diarrhoea and to aid in developing new vaccines. Centralised repositories that enable mining of large data sets to better characterise risk factors, the proteome of both the patient and the different diarrhoeal pathogens, and the environment, could inform patient management and vaccine development, providing a systems biological approach to address the burden of childhood diarrhoea in LMICs.
format	article
author	Karen H. Keddy Senjuti Saha Iruka N. Okeke John Bosco Kalule Farah Naz Qamar Samuel Kariuki
author_facet	Karen H. Keddy Senjuti Saha Iruka N. Okeke John Bosco Kalule Farah Naz Qamar Samuel Kariuki
author_sort	Karen H. Keddy
title	Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries
title_short	Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries
title_full	Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries
title_fullStr	Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries
title_full_unstemmed	Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries
title_sort	big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in low- and middle-income countries
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8e658ac362384d11bcbd0a5291b91be9
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Big data, biomarkers and proteomics: informing childhood diarrhoeal disease management in Low- and Middle-Income Countries

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