Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)

Abstract Kidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,...

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Autores principales:	Hye Jin Joo, Gyu Ri Kim, Dong-Woo Choi, Jae Hong Joo, Eun-Cheol Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e698f6a8af44e3ea2d711af82f903a4
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spelling	oai:doaj.org-article:8e698f6a8af44e3ea2d711af82f903a42021-12-02T11:43:51ZUric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)10.1038/s41598-020-77702-x2045-2322https://doaj.org/article/8e698f6a8af44e3ea2d711af82f903a42020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77702-xhttps://doaj.org/toc/2045-2322Abstract Kidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,042 participants of the 2016–2017 Korea National Health and Nutrition Examination Survey were analysed. The estimated glomerular filtration rate was calculated using the modification of diet in renal disease formula for Koreans. For each sex, uric acid levels were divided into five subsequent categories of increasing levels (Q1, Q2, Q3, Q4, and hyperuricemia). The association between uric acid level and kidney function was investigated using multiple logistic regression. The results showed that the higher the uric acid levels, the greater the odds of reduced kidney function in both sexes. In men, the adjusted odds ratios (95% confidence intervals) for reduced eGFR comparing the hyperuricemia group to the lowest serum uric acid quartile was 5.55 (3.27–9.44), and in women, the odds ratios (95% confidence intervals) was 7.52 (4.39–12.87). Normal weight or underweight in men and overweight in women, as well as diabetes mellitus, hypertension, and physical inactivity were highly associated with reduced kidney function. Our study revealed a dose–response relationship between uric acid levels and kidney function. Therefore, high uric acid level should be considered as a factor that is potentially related to kidney dysfunction in the Korean population.Hye Jin JooGyu Ri KimDong-Woo ChoiJae Hong JooEun-Cheol ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Jin Joo Gyu Ri Kim Dong-Woo Choi Jae Hong Joo Eun-Cheol Park Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)
description	Abstract Kidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,042 participants of the 2016–2017 Korea National Health and Nutrition Examination Survey were analysed. The estimated glomerular filtration rate was calculated using the modification of diet in renal disease formula for Koreans. For each sex, uric acid levels were divided into five subsequent categories of increasing levels (Q1, Q2, Q3, Q4, and hyperuricemia). The association between uric acid level and kidney function was investigated using multiple logistic regression. The results showed that the higher the uric acid levels, the greater the odds of reduced kidney function in both sexes. In men, the adjusted odds ratios (95% confidence intervals) for reduced eGFR comparing the hyperuricemia group to the lowest serum uric acid quartile was 5.55 (3.27–9.44), and in women, the odds ratios (95% confidence intervals) was 7.52 (4.39–12.87). Normal weight or underweight in men and overweight in women, as well as diabetes mellitus, hypertension, and physical inactivity were highly associated with reduced kidney function. Our study revealed a dose–response relationship between uric acid levels and kidney function. Therefore, high uric acid level should be considered as a factor that is potentially related to kidney dysfunction in the Korean population.
format	article
author	Hye Jin Joo Gyu Ri Kim Dong-Woo Choi Jae Hong Joo Eun-Cheol Park
author_facet	Hye Jin Joo Gyu Ri Kim Dong-Woo Choi Jae Hong Joo Eun-Cheol Park
author_sort	Hye Jin Joo
title	Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)
title_short	Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)
title_full	Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)
title_fullStr	Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)
title_full_unstemmed	Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)
title_sort	uric acid level and kidney function: a cross-sectional study of the korean national health and nutrition examination survey (2016–2017)
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e698f6a8af44e3ea2d711af82f903a4
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Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)

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