Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid

Thirapit Subongkot,1 Tanasait Ngawhirunpat2 1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Abstract: This stu...

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Autores principales:	Subongkot T, Ngawhirunpat T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	microemulsion all-trans retinoic acid oral absorption enhancement oleth-5 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8e6a7326966d422b8d8089194f431f28
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spelling	oai:doaj.org-article:8e6a7326966d422b8d8089194f431f282021-12-02T01:49:53ZDevelopment of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid1178-2013https://doaj.org/article/8e6a7326966d422b8d8089194f431f282017-08-01T00:00:00Zhttps://www.dovepress.com/development-of-a-novel-microemulsion-for-oral-absorption-enhancement-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Thirapit Subongkot,1 Tanasait Ngawhirunpat2 1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Abstract: This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was evaluated for its particle size, shape, zeta potential, in vitro release, in vitro intestinal absorption, intestinal membrane cytotoxicity and stability. The obtained microemulsion was spherical in shape with a particle size of <200 nm and a negative surface charge. The in vitro release of the ATRA-loaded microemulsion was best fit with the zero-order model. This microemulsion significantly improved the intestinal absorption of ATRA. Confocal laser scanning microscopy analysis using a fluorescent dye-loaded microemulsion also confirmed the intestinal absorption result. The intestinal membrane cytotoxicity of the ATRA-loaded microemulsion did not differ from an edible oil (fish oil). Stability testing showed that the ATRA-loaded microemulsion was more stable at 25°C than 40°C. Keywords: microemulsion, all-trans retinoic acid, oral absorption enhancement, oleth-5, fish oilSubongkot TNgawhirunpat TDove Medical Pressarticlemicroemulsionall-trans retinoic acidoral absorption enhancementoleth-5Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5585-5599 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	microemulsion all-trans retinoic acid oral absorption enhancement oleth-5 Medicine (General) R5-920
spellingShingle	microemulsion all-trans retinoic acid oral absorption enhancement oleth-5 Medicine (General) R5-920 Subongkot T Ngawhirunpat T Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
description	Thirapit Subongkot,1 Tanasait Ngawhirunpat2 1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Abstract: This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was evaluated for its particle size, shape, zeta potential, in vitro release, in vitro intestinal absorption, intestinal membrane cytotoxicity and stability. The obtained microemulsion was spherical in shape with a particle size of <200 nm and a negative surface charge. The in vitro release of the ATRA-loaded microemulsion was best fit with the zero-order model. This microemulsion significantly improved the intestinal absorption of ATRA. Confocal laser scanning microscopy analysis using a fluorescent dye-loaded microemulsion also confirmed the intestinal absorption result. The intestinal membrane cytotoxicity of the ATRA-loaded microemulsion did not differ from an edible oil (fish oil). Stability testing showed that the ATRA-loaded microemulsion was more stable at 25°C than 40°C. Keywords: microemulsion, all-trans retinoic acid, oral absorption enhancement, oleth-5, fish oil
format	article
author	Subongkot T Ngawhirunpat T
author_facet	Subongkot T Ngawhirunpat T
author_sort	Subongkot T
title	Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
title_short	Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
title_full	Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
title_fullStr	Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
title_full_unstemmed	Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
title_sort	development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8e6a7326966d422b8d8089194f431f28
work_keys_str_mv	AT subongkott developmentofanovelmicroemulsionfororalabsorptionenhancementofalltransretinoicacid AT ngawhirunpatt developmentofanovelmicroemulsionfororalabsorptionenhancementofalltransretinoicacid
_version_	1718402854344982528

Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid

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