Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in <named-content content-type="genus-species">Leishmania major</named-content>

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Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in <named-content content-type="genus-species">Leishmania major</named-content>

ABSTRACT Lathosterol oxidase (LSO) catalyzes the formation of the C-5–C-6 double bond in the synthesis of various types of sterols in mammals, fungi, plants, and protozoa. In Leishmania parasites, mutations in LSO or other sterol biosynthetic genes are associated with amphotericin B resistance. To i...

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Detalles Bibliográficos
Autores principales:	Yu Ning, Cheryl Frankfater, Fong-Fu Hsu, Rodrigo P. Soares, Camila A. Cardoso, Paula M. Nogueira, Noelia Marina Lander, Roberto Docampo, Kai Zhang
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Leishmania amphotericin drug resistance mechanisms lipid synthesis sterols stress response Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8e6b658ffd5043579442d11bcb0da4ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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