Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics

Digital microfluidics (DMF) is a versatile fluid handling tool that is widely used in the biochemical field. There are very high requirements for the volume of single droplet in many biochemical applications. Droplet dispensing and splitting are two main operations to generate a single droplet in DM...

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Autores principales:	Wang He, Chen Liguo
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	digital microfluidics electrode geometry optimization dispensing splitting volume precision volume accuracy Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/8e6ce8c79e5a47b490cef60660dbd9f4
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id	oai:doaj.org-article:8e6ce8c79e5a47b490cef60660dbd9f4
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spelling	oai:doaj.org-article:8e6ce8c79e5a47b490cef60660dbd9f42021-12-05T14:10:58ZNovel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics2191-909710.1515/ntrev-2021-0054https://doaj.org/article/8e6ce8c79e5a47b490cef60660dbd9f42021-08-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0054https://doaj.org/toc/2191-9097Digital microfluidics (DMF) is a versatile fluid handling tool that is widely used in the biochemical field. There are very high requirements for the volume of single droplet in many biochemical applications. Droplet dispensing and splitting are two main operations to generate a single droplet in DMF. Therefore, the generation of droplets with high volume precision and accuracy in the two droplet operations is one of the keys to the efficient application of DMF in biochemical analysis. We have developed a novel droplet dispensing and splitting scheme where electrode geometry is optimized. The liquid column can contract in a regular shape, which keep the neck shape uniform and stable, and the position of pinch-off point was fixed; meanwhile, the liquid tail is eliminated before pinching off, so that the precision and accuracy of droplet volume were greatly improved. The increase in the radius of the cutting electrodes elongated the droplet neck and increased the neck curvature at the pinch-off point, which further effectively improved the precision and accuracy of droplet volume. The optimized droplet splitting scheme can also be applied to the droplet splitting with unequal volume effectively.Wang HeChen LiguoDe Gruyterarticledigital microfluidicselectrode geometry optimizationdispensingsplittingvolume precisionvolume accuracyTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 857-869 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	digital microfluidics electrode geometry optimization dispensing splitting volume precision volume accuracy Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	digital microfluidics electrode geometry optimization dispensing splitting volume precision volume accuracy Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Wang He Chen Liguo Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
description	Digital microfluidics (DMF) is a versatile fluid handling tool that is widely used in the biochemical field. There are very high requirements for the volume of single droplet in many biochemical applications. Droplet dispensing and splitting are two main operations to generate a single droplet in DMF. Therefore, the generation of droplets with high volume precision and accuracy in the two droplet operations is one of the keys to the efficient application of DMF in biochemical analysis. We have developed a novel droplet dispensing and splitting scheme where electrode geometry is optimized. The liquid column can contract in a regular shape, which keep the neck shape uniform and stable, and the position of pinch-off point was fixed; meanwhile, the liquid tail is eliminated before pinching off, so that the precision and accuracy of droplet volume were greatly improved. The increase in the radius of the cutting electrodes elongated the droplet neck and increased the neck curvature at the pinch-off point, which further effectively improved the precision and accuracy of droplet volume. The optimized droplet splitting scheme can also be applied to the droplet splitting with unequal volume effectively.
format	article
author	Wang He Chen Liguo
author_facet	Wang He Chen Liguo
author_sort	Wang He
title	Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
title_short	Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
title_full	Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
title_fullStr	Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
title_full_unstemmed	Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
title_sort	novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/8e6ce8c79e5a47b490cef60660dbd9f4
work_keys_str_mv	AT wanghe novelelectrodesforpreciseandaccuratedropletdispensingandsplittingindigitalmicrofluidics AT chenliguo novelelectrodesforpreciseandaccuratedropletdispensingandsplittingindigitalmicrofluidics
_version_	1718371553801928704

Novel electrodes for precise and accurate droplet dispensing and splitting in digital microfluidics

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