Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study

The hallmark of resting EEG spectra are distinct rhythms emerging from a broadband, aperiodic background. This aperiodic neural signature accounts for most of total EEG power, although its significance and relation to functional neuroanatomy remains obscure. We hypothesized that aperiodic EEG reflec...

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Autores principales:	Michael S. Jacob, Brian J. Roach, Kaia S. Sargent, Daniel H. Mathalon, Judith M. Ford
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Scale-free Aperiodic Resting-state EEG-fMRI Neurometabolic coupling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/8e6ddca4c7de409a9303134ad5f79d4f
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spelling	oai:doaj.org-article:8e6ddca4c7de409a9303134ad5f79d4f2021-11-28T04:28:58ZAperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study1095-957210.1016/j.neuroimage.2021.118705https://doaj.org/article/8e6ddca4c7de409a9303134ad5f79d4f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009770https://doaj.org/toc/1095-9572The hallmark of resting EEG spectra are distinct rhythms emerging from a broadband, aperiodic background. This aperiodic neural signature accounts for most of total EEG power, although its significance and relation to functional neuroanatomy remains obscure. We hypothesized that aperiodic EEG reflects a significant metabolic expenditure and therefore might be associated with the default mode network while at rest. During eyes-open, resting-state recordings of simultaneous EEG-fMRI, we find that aperiodic and periodic components of EEG power are only minimally associated with activity in the default mode network. However, a whole-brain analysis identifies increases in aperiodic power correlated with hemodynamic activity in an auditory-salience-cerebellar network, and decreases in aperiodic power are correlated with hemodynamic activity in prefrontal regions. Desynchronization in residual alpha and beta power is associated with visual and sensorimotor hemodynamic activity, respectively. These findings suggest that resting-state EEG signals acquired in an fMRI scanner reflect a balance of top-down and bottom-up stimulus processing, even in the absence of an explicit task.Michael S. JacobBrian J. RoachKaia S. SargentDaniel H. MathalonJudith M. FordElsevierarticleScale-freeAperiodicResting-stateEEG-fMRINeurometabolic couplingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118705- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Scale-free Aperiodic Resting-state EEG-fMRI Neurometabolic coupling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Scale-free Aperiodic Resting-state EEG-fMRI Neurometabolic coupling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Michael S. Jacob Brian J. Roach Kaia S. Sargent Daniel H. Mathalon Judith M. Ford Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study
description	The hallmark of resting EEG spectra are distinct rhythms emerging from a broadband, aperiodic background. This aperiodic neural signature accounts for most of total EEG power, although its significance and relation to functional neuroanatomy remains obscure. We hypothesized that aperiodic EEG reflects a significant metabolic expenditure and therefore might be associated with the default mode network while at rest. During eyes-open, resting-state recordings of simultaneous EEG-fMRI, we find that aperiodic and periodic components of EEG power are only minimally associated with activity in the default mode network. However, a whole-brain analysis identifies increases in aperiodic power correlated with hemodynamic activity in an auditory-salience-cerebellar network, and decreases in aperiodic power are correlated with hemodynamic activity in prefrontal regions. Desynchronization in residual alpha and beta power is associated with visual and sensorimotor hemodynamic activity, respectively. These findings suggest that resting-state EEG signals acquired in an fMRI scanner reflect a balance of top-down and bottom-up stimulus processing, even in the absence of an explicit task.
format	article
author	Michael S. Jacob Brian J. Roach Kaia S. Sargent Daniel H. Mathalon Judith M. Ford
author_facet	Michael S. Jacob Brian J. Roach Kaia S. Sargent Daniel H. Mathalon Judith M. Ford
author_sort	Michael S. Jacob
title	Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study
title_short	Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study
title_full	Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study
title_fullStr	Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study
title_full_unstemmed	Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study
title_sort	aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: a combined eeg-fmri study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8e6ddca4c7de409a9303134ad5f79d4f
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Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: A combined EEG-fMRI study

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