Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm

Gastric-type adenocarcinoma of the uterine cervix (GAS) is a rare subtype of mucinous adenocarcinoma, unrelated to HPV infection. It first appeared in the World Health Organization Classification of Tumours of Female Reproductive Organs in 2014.This report discusses a 50-year-old, Caucasian female w...

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Autores principales:	Jamie L. McDowell, Nicole Joseph, Pallvi K. Singh, Hong Yin, Scott C. Purinton
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cervical cancer Gastric type Adenocarcinoma Gynecology and obstetrics RG1-991 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8e6e1a946f574219a2e77f923e167d02
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spelling	oai:doaj.org-article:8e6e1a946f574219a2e77f923e167d022021-11-18T04:50:17ZGastric type adenocarcinoma of the cervix presenting as ovarian neoplasm2352-578910.1016/j.gore.2021.100888https://doaj.org/article/8e6e1a946f574219a2e77f923e167d022021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352578921001922https://doaj.org/toc/2352-5789Gastric-type adenocarcinoma of the uterine cervix (GAS) is a rare subtype of mucinous adenocarcinoma, unrelated to HPV infection. It first appeared in the World Health Organization Classification of Tumours of Female Reproductive Organs in 2014.This report discusses a 50-year-old, Caucasian female who presented with new onset abdominal pain, distension, and diffuse ascites. CT scan revealed an ovarian neoplasm later diagnosed as GAS on surgical pathology. Immunohistological stains were positive for PAX8, CK7, CK20 (focally strong), CAIX (strong), CEA (patchy), MUC6 (strong), HNF1b, UBC, RNA, KOC (focal), and P53 (wild type). Tumor cells were negative for p16, PAX2, ER, low-risk 5 HPV, high-risk 18 HPV, and CDX2. The proliferative index (Ki-67) was 20%. The patient is scheduled to receive systemic chemotherapy of cisplatin, paclitaxel, and bevacizumab. Following chemotherapy, she will undergo external beam radiation and vaginal brachytherapy.The prevalence of GAS in the United States is currently unknown. Little is understood about the ideal treatment for this disease, and prognosis is very poor. As more cases are identified and reported, more targeted therapy be developed and trialed in these patients.Jamie L. McDowellNicole JosephPallvi K. SinghHong YinScott C. PurintonElsevierarticleCervical cancerGastric typeAdenocarcinomaGynecology and obstetricsRG1-991Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENGynecologic Oncology Reports, Vol 38, Iss , Pp 100888- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical cancer Gastric type Adenocarcinoma Gynecology and obstetrics RG1-991 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Cervical cancer Gastric type Adenocarcinoma Gynecology and obstetrics RG1-991 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jamie L. McDowell Nicole Joseph Pallvi K. Singh Hong Yin Scott C. Purinton Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
description	Gastric-type adenocarcinoma of the uterine cervix (GAS) is a rare subtype of mucinous adenocarcinoma, unrelated to HPV infection. It first appeared in the World Health Organization Classification of Tumours of Female Reproductive Organs in 2014.This report discusses a 50-year-old, Caucasian female who presented with new onset abdominal pain, distension, and diffuse ascites. CT scan revealed an ovarian neoplasm later diagnosed as GAS on surgical pathology. Immunohistological stains were positive for PAX8, CK7, CK20 (focally strong), CAIX (strong), CEA (patchy), MUC6 (strong), HNF1b, UBC, RNA, KOC (focal), and P53 (wild type). Tumor cells were negative for p16, PAX2, ER, low-risk 5 HPV, high-risk 18 HPV, and CDX2. The proliferative index (Ki-67) was 20%. The patient is scheduled to receive systemic chemotherapy of cisplatin, paclitaxel, and bevacizumab. Following chemotherapy, she will undergo external beam radiation and vaginal brachytherapy.The prevalence of GAS in the United States is currently unknown. Little is understood about the ideal treatment for this disease, and prognosis is very poor. As more cases are identified and reported, more targeted therapy be developed and trialed in these patients.
format	article
author	Jamie L. McDowell Nicole Joseph Pallvi K. Singh Hong Yin Scott C. Purinton
author_facet	Jamie L. McDowell Nicole Joseph Pallvi K. Singh Hong Yin Scott C. Purinton
author_sort	Jamie L. McDowell
title	Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
title_short	Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
title_full	Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
title_fullStr	Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
title_full_unstemmed	Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
title_sort	gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8e6e1a946f574219a2e77f923e167d02
work_keys_str_mv	AT jamielmcdowell gastrictypeadenocarcinomaofthecervixpresentingasovarianneoplasm AT nicolejoseph gastrictypeadenocarcinomaofthecervixpresentingasovarianneoplasm AT pallviksingh gastrictypeadenocarcinomaofthecervixpresentingasovarianneoplasm AT hongyin gastrictypeadenocarcinomaofthecervixpresentingasovarianneoplasm AT scottcpurinton gastrictypeadenocarcinomaofthecervixpresentingasovarianneoplasm
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Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm

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