First case of fungal keratitis caused by Pestalotiopsis clavispora

Yu Monden,1 Shohaku Yamamoto,1 Ryoji Yamakawa,1 Atsuko Sunada,2 Seishi Asari,3 Koichi Makimura,4 Yoshitsugu Inoue5 1Department of Ophthalmology, Kurume University School of Medicine, Fukuoka, 2Laboratory for Clinical Investigation, 3Department of Infection Control and Prevention, Osaka University Ho...

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Autores principales:	Monden Y, Yamamoto S, Yamakawa R, Sunada A, Asari S, Makimura K, Inoue Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8e6fa6c4db1d4804bd30aab42c02097b
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spelling	oai:doaj.org-article:8e6fa6c4db1d4804bd30aab42c02097b2021-12-02T02:19:32ZFirst case of fungal keratitis caused by Pestalotiopsis clavispora1177-54671177-5483https://doaj.org/article/8e6fa6c4db1d4804bd30aab42c02097b2013-11-01T00:00:00Zhttp://www.dovepress.com/first-case-of-fungal-keratitis-caused-by-pestalotiopsis-clavispora-a15101https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yu Monden,1 Shohaku Yamamoto,1 Ryoji Yamakawa,1 Atsuko Sunada,2 Seishi Asari,3 Koichi Makimura,4 Yoshitsugu Inoue5 1Department of Ophthalmology, Kurume University School of Medicine, Fukuoka, 2Laboratory for Clinical Investigation, 3Department of Infection Control and Prevention, Osaka University Hospital, Osaka, 4Teikyo University Institute of Medical Mycology, Tokyo, 5Division of Ophthalmology and Visual Sciences, Tottori University Faculty of Medicine, Tottori, Japan Purpose: To report the isolation of Pestalotiopsis clavispora from the cornea of a patient with recurrent keratitis. Case report: A 73-year-old male gardener presented with conjunctival injection and an oval infiltrate with feathery margins in the temporal half of the cornea in the right eye. His ocular history in the right eye included cataract surgery, five episodes of herpes simplex keratitis, three glaucoma surgeries, and bullous keratopathy. He had been treated with corticosteroids for years. Light microscopy of corneal scrapings revealed a filamentous fungus, and fungal keratitis was diagnosed. Treatment with topical voriconazole and pimaricin ointment was commenced. One month later, the infiltrate resolved. The antifungal agents were discontinued 7 months later, and keratitis relapsed 4 days after the discontinuation. The fungus was isolated and identified by molecular techniques as P. clavispora. Based on the results of antifungal susceptibility testing, treatment with topical and intravenous micafungin was initiated. The corneal infiltrate resolved 1 month after the relapse. Conclusion: Molecular identification of the pathogen, and antifungal susceptibility testing, are useful in treating patients with fungal keratitis caused by a rare human pathogen. Keywords: fungal keratitis, Pestalotiopsis clavispora, plant pathogen, molecular identification, antifungal susceptibility testMonden YYamamoto SYamakawa RSunada AAsari SMakimura KInoue YDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2261-2264 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Monden Y Yamamoto S Yamakawa R Sunada A Asari S Makimura K Inoue Y First case of fungal keratitis caused by Pestalotiopsis clavispora
description	Yu Monden,1 Shohaku Yamamoto,1 Ryoji Yamakawa,1 Atsuko Sunada,2 Seishi Asari,3 Koichi Makimura,4 Yoshitsugu Inoue5 1Department of Ophthalmology, Kurume University School of Medicine, Fukuoka, 2Laboratory for Clinical Investigation, 3Department of Infection Control and Prevention, Osaka University Hospital, Osaka, 4Teikyo University Institute of Medical Mycology, Tokyo, 5Division of Ophthalmology and Visual Sciences, Tottori University Faculty of Medicine, Tottori, Japan Purpose: To report the isolation of Pestalotiopsis clavispora from the cornea of a patient with recurrent keratitis. Case report: A 73-year-old male gardener presented with conjunctival injection and an oval infiltrate with feathery margins in the temporal half of the cornea in the right eye. His ocular history in the right eye included cataract surgery, five episodes of herpes simplex keratitis, three glaucoma surgeries, and bullous keratopathy. He had been treated with corticosteroids for years. Light microscopy of corneal scrapings revealed a filamentous fungus, and fungal keratitis was diagnosed. Treatment with topical voriconazole and pimaricin ointment was commenced. One month later, the infiltrate resolved. The antifungal agents were discontinued 7 months later, and keratitis relapsed 4 days after the discontinuation. The fungus was isolated and identified by molecular techniques as P. clavispora. Based on the results of antifungal susceptibility testing, treatment with topical and intravenous micafungin was initiated. The corneal infiltrate resolved 1 month after the relapse. Conclusion: Molecular identification of the pathogen, and antifungal susceptibility testing, are useful in treating patients with fungal keratitis caused by a rare human pathogen. Keywords: fungal keratitis, Pestalotiopsis clavispora, plant pathogen, molecular identification, antifungal susceptibility test
format	article
author	Monden Y Yamamoto S Yamakawa R Sunada A Asari S Makimura K Inoue Y
author_facet	Monden Y Yamamoto S Yamakawa R Sunada A Asari S Makimura K Inoue Y
author_sort	Monden Y
title	First case of fungal keratitis caused by Pestalotiopsis clavispora
title_short	First case of fungal keratitis caused by Pestalotiopsis clavispora
title_full	First case of fungal keratitis caused by Pestalotiopsis clavispora
title_fullStr	First case of fungal keratitis caused by Pestalotiopsis clavispora
title_full_unstemmed	First case of fungal keratitis caused by Pestalotiopsis clavispora
title_sort	first case of fungal keratitis caused by pestalotiopsis clavispora
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/8e6fa6c4db1d4804bd30aab42c02097b
work_keys_str_mv	AT mondeny firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora AT yamamotos firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora AT yamakawar firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora AT sunadaa firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora AT asaris firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora AT makimurak firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora AT inouey firstcaseoffungalkeratitiscausedbypestalotiopsisclavispora
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First case of fungal keratitis caused by Pestalotiopsis clavispora

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