Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut

ABSTRACT Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bact...

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Autor principal:	Jeremy J. Barr
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	bacteriophage symbioses gut microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8e71f3e3e6084413ba2d258237899264
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spelling	oai:doaj.org-article:8e71f3e3e6084413ba2d2582378992642021-12-02T19:46:18ZMissing a Phage: Unraveling Tripartite Symbioses within the Human Gut10.1128/mSystems.00105-192379-5077https://doaj.org/article/8e71f3e3e6084413ba2d2582378992642019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00105-19https://doaj.org/toc/2379-5077ABSTRACT Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bacterial hosts and thereby to facilitate indirect interactions with the epithelial cell layers, and yet a growing body of literature is demonstrating the surprising and diverse ways in which phages directly interact with the eukaryotic cells, organs, and systems of the body. Phages can adhere to mucosal surfaces, bind and transcytose epithelial cells, and deliver proteins and nucleic acids to eukaryotic cells directly. These interactions could establish positive-feedback loops leading to the selection of bacterial hosts and their phage symbionts in the gut. The members of my laboratory are working to expand our knowledge on the phage-eukaryote interactions and to redefine the concept of tripartite symbioses within the human body.Jeremy J. BarrAmerican Society for MicrobiologyarticlebacteriophagesymbiosesgutmicrobiomeMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteriophage symbioses gut microbiome Microbiology QR1-502
spellingShingle	bacteriophage symbioses gut microbiome Microbiology QR1-502 Jeremy J. Barr Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
description	ABSTRACT Tripartite symbioses between bacteriophages, the epithelial cell layers of the human gut, and bacterial symbionts may play an important and unrecognized role in the function of the gut microbiome. Traditionally, phages residing within the gut were considered to interact only with their bacterial hosts and thereby to facilitate indirect interactions with the epithelial cell layers, and yet a growing body of literature is demonstrating the surprising and diverse ways in which phages directly interact with the eukaryotic cells, organs, and systems of the body. Phages can adhere to mucosal surfaces, bind and transcytose epithelial cells, and deliver proteins and nucleic acids to eukaryotic cells directly. These interactions could establish positive-feedback loops leading to the selection of bacterial hosts and their phage symbionts in the gut. The members of my laboratory are working to expand our knowledge on the phage-eukaryote interactions and to redefine the concept of tripartite symbioses within the human body.
format	article
author	Jeremy J. Barr
author_facet	Jeremy J. Barr
author_sort	Jeremy J. Barr
title	Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
title_short	Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
title_full	Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
title_fullStr	Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
title_full_unstemmed	Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut
title_sort	missing a phage: unraveling tripartite symbioses within the human gut
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/8e71f3e3e6084413ba2d258237899264
work_keys_str_mv	AT jeremyjbarr missingaphageunravelingtripartitesymbioseswithinthehumangut
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Missing a Phage: Unraveling Tripartite Symbioses within the Human Gut

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