Somatic Reprogramming—Above and Beyond Pluripotency

Pluripotent stem cells, having long been considered the fountain of youth, have caught the attention of many researchers from diverse backgrounds due to their capacity for unlimited self-renewal and potential to differentiate into all cell types. Over the past 15 years, the advanced development of i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yaa-Jyuhn James Meir, Guigang Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	induced pluripotent stem cell (iPSC) somatic reprogramming Col1a1 4F2A Oct4-GFP reprogrammable mouse stochastic and deterministic model expanded potential stem cell (EPSC) expanded potential stem cell medium (EPSCM) Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8e72c2e72cc1443d9fe5a02f3269af35
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e72c2e72cc1443d9fe5a02f3269af35
record_format	dspace
spelling	oai:doaj.org-article:8e72c2e72cc1443d9fe5a02f3269af352021-11-25T17:08:35ZSomatic Reprogramming—Above and Beyond Pluripotency10.3390/cells101128882073-4409https://doaj.org/article/8e72c2e72cc1443d9fe5a02f3269af352021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2888https://doaj.org/toc/2073-4409Pluripotent stem cells, having long been considered the fountain of youth, have caught the attention of many researchers from diverse backgrounds due to their capacity for unlimited self-renewal and potential to differentiate into all cell types. Over the past 15 years, the advanced development of induced pluripotent stem cells (iPSCs) has displayed an unparalleled potential for regenerative medicine, cell-based therapies, modeling human diseases in culture, and drug discovery. The transcription factor quartet (Oct4, Sox2, Klf4, and c-Myc) reprograms highly differentiated somatic cells back to a pluripotent state recapitulated embryonic stem cells (ESCs) in different aspects, including gene expression profile, epigenetic signature, and functional pluripotency. With the prior fruitful studies in SCNT and cell fusion experiments, iPSC finds its place and implicates that the differentiated somatic epigenome retains plasticity for re-gaining the pluripotency and further stretchability to reach a totipotency-like state. These achievements have revolutionized the concept and created a new avenue in biomedical sciences for clinical applications. With the advent of 15 years’ progress-making after iPSC discovery, this review is focused on how the current concept is established by revisiting those essential landmark studies and summarizing its current biomedical applications status to facilitate the new era entry of regenerative therapy.Yaa-Jyuhn James MeirGuigang LiMDPI AGarticleinduced pluripotent stem cell (iPSC)somatic reprogrammingCol1a1 4F2A Oct4-GFP reprogrammable mousestochastic and deterministic modelexpanded potential stem cell (EPSC)expanded potential stem cell medium (EPSCM)Biology (General)QH301-705.5ENCells, Vol 10, Iss 2888, p 2888 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	induced pluripotent stem cell (iPSC) somatic reprogramming Col1a1 4F2A Oct4-GFP reprogrammable mouse stochastic and deterministic model expanded potential stem cell (EPSC) expanded potential stem cell medium (EPSCM) Biology (General) QH301-705.5
spellingShingle	induced pluripotent stem cell (iPSC) somatic reprogramming Col1a1 4F2A Oct4-GFP reprogrammable mouse stochastic and deterministic model expanded potential stem cell (EPSC) expanded potential stem cell medium (EPSCM) Biology (General) QH301-705.5 Yaa-Jyuhn James Meir Guigang Li Somatic Reprogramming—Above and Beyond Pluripotency
description	Pluripotent stem cells, having long been considered the fountain of youth, have caught the attention of many researchers from diverse backgrounds due to their capacity for unlimited self-renewal and potential to differentiate into all cell types. Over the past 15 years, the advanced development of induced pluripotent stem cells (iPSCs) has displayed an unparalleled potential for regenerative medicine, cell-based therapies, modeling human diseases in culture, and drug discovery. The transcription factor quartet (Oct4, Sox2, Klf4, and c-Myc) reprograms highly differentiated somatic cells back to a pluripotent state recapitulated embryonic stem cells (ESCs) in different aspects, including gene expression profile, epigenetic signature, and functional pluripotency. With the prior fruitful studies in SCNT and cell fusion experiments, iPSC finds its place and implicates that the differentiated somatic epigenome retains plasticity for re-gaining the pluripotency and further stretchability to reach a totipotency-like state. These achievements have revolutionized the concept and created a new avenue in biomedical sciences for clinical applications. With the advent of 15 years’ progress-making after iPSC discovery, this review is focused on how the current concept is established by revisiting those essential landmark studies and summarizing its current biomedical applications status to facilitate the new era entry of regenerative therapy.
format	article
author	Yaa-Jyuhn James Meir Guigang Li
author_facet	Yaa-Jyuhn James Meir Guigang Li
author_sort	Yaa-Jyuhn James Meir
title	Somatic Reprogramming—Above and Beyond Pluripotency
title_short	Somatic Reprogramming—Above and Beyond Pluripotency
title_full	Somatic Reprogramming—Above and Beyond Pluripotency
title_fullStr	Somatic Reprogramming—Above and Beyond Pluripotency
title_full_unstemmed	Somatic Reprogramming—Above and Beyond Pluripotency
title_sort	somatic reprogramming—above and beyond pluripotency
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8e72c2e72cc1443d9fe5a02f3269af35
work_keys_str_mv	AT yaajyuhnjamesmeir somaticreprogrammingaboveandbeyondpluripotency AT guigangli somaticreprogrammingaboveandbeyondpluripotency
_version_	1718412664199184384

Somatic Reprogramming—Above and Beyond Pluripotency

Ejemplares similares