Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke
Abstract In patients with acute ischemic stroke, pial collaterals play a key role in limiting neurological disability by maintaining blood flow to ischemic penumbra. We hypothesized that patient with poor pial collaterals will have greater corneal nerve and endothelial cell abnormalities. In a cross...
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Nature Portfolio
2021
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oai:doaj.org-article:8e73ac56e3ec4ffc9d82de6f3c1032262021-12-02T16:56:48ZCorneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke10.1038/s41598-021-99131-02045-2322https://doaj.org/article/8e73ac56e3ec4ffc9d82de6f3c1032262021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99131-0https://doaj.org/toc/2045-2322Abstract In patients with acute ischemic stroke, pial collaterals play a key role in limiting neurological disability by maintaining blood flow to ischemic penumbra. We hypothesized that patient with poor pial collaterals will have greater corneal nerve and endothelial cell abnormalities. In a cross-sectional study, 35 patients with acute ischemic stroke secondary to middle cerebral artery (MCA) occlusion with poor (n = 12) and moderate-good (n = 23) pial collaterals and 35 healthy controls underwent corneal confocal microscopy and quantification of corneal nerve and endothelial cell morphology. In patients with MCA stroke, corneal nerve fibre length (CNFL) (P < 0.001), corneal nerve fibre density (CNFD) (P = 0.025) and corneal nerve branch density (CNBD) (P = 0.002) were lower compared to controls. Age, BMI, cholesterol, triglycerides, HDL, LDL, systolic blood pressure, NIHSS and endothelial cell parameters did not differ but mRS was higher (p = 0.023) and CNFL (p = 0.026) and CNBD (p = 0.044) were lower in patients with poor compared to moderate-good collaterals. CNFL and CNBD distinguished subjects with poor from moderate-good pial collaterals with an AUC of 72% (95% CI 53–92%) and 71% (95% CI 53–90%), respectively. Corneal nerve loss is greater in patients with poor compared to moderate-good pial collaterals and may act as a surrogate marker for pial collateral status in patients with ischemic stroke.Adnan KhanAjay MenonNaveed AkhtarSaadat KamranAhmad MuhammadGeorgios PonirakisHoda GadIoannis N. PetropoulosFaisal WadiwalaBlessy BabuAdeeb M. NarangoliPablo G. BermejoHanadi Al HamadMarwan RamadanPeter WoodruffMark SantosMaher SaqqurAshfaq ShuaibRayaz A. MalikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Adnan Khan Ajay Menon Naveed Akhtar Saadat Kamran Ahmad Muhammad Georgios Ponirakis Hoda Gad Ioannis N. Petropoulos Faisal Wadiwala Blessy Babu Adeeb M. Narangoli Pablo G. Bermejo Hanadi Al Hamad Marwan Ramadan Peter Woodruff Mark Santos Maher Saqqur Ashfaq Shuaib Rayaz A. Malik Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| description |
Abstract In patients with acute ischemic stroke, pial collaterals play a key role in limiting neurological disability by maintaining blood flow to ischemic penumbra. We hypothesized that patient with poor pial collaterals will have greater corneal nerve and endothelial cell abnormalities. In a cross-sectional study, 35 patients with acute ischemic stroke secondary to middle cerebral artery (MCA) occlusion with poor (n = 12) and moderate-good (n = 23) pial collaterals and 35 healthy controls underwent corneal confocal microscopy and quantification of corneal nerve and endothelial cell morphology. In patients with MCA stroke, corneal nerve fibre length (CNFL) (P < 0.001), corneal nerve fibre density (CNFD) (P = 0.025) and corneal nerve branch density (CNBD) (P = 0.002) were lower compared to controls. Age, BMI, cholesterol, triglycerides, HDL, LDL, systolic blood pressure, NIHSS and endothelial cell parameters did not differ but mRS was higher (p = 0.023) and CNFL (p = 0.026) and CNBD (p = 0.044) were lower in patients with poor compared to moderate-good collaterals. CNFL and CNBD distinguished subjects with poor from moderate-good pial collaterals with an AUC of 72% (95% CI 53–92%) and 71% (95% CI 53–90%), respectively. Corneal nerve loss is greater in patients with poor compared to moderate-good pial collaterals and may act as a surrogate marker for pial collateral status in patients with ischemic stroke. |
| format |
article |
| author |
Adnan Khan Ajay Menon Naveed Akhtar Saadat Kamran Ahmad Muhammad Georgios Ponirakis Hoda Gad Ioannis N. Petropoulos Faisal Wadiwala Blessy Babu Adeeb M. Narangoli Pablo G. Bermejo Hanadi Al Hamad Marwan Ramadan Peter Woodruff Mark Santos Maher Saqqur Ashfaq Shuaib Rayaz A. Malik |
| author_facet |
Adnan Khan Ajay Menon Naveed Akhtar Saadat Kamran Ahmad Muhammad Georgios Ponirakis Hoda Gad Ioannis N. Petropoulos Faisal Wadiwala Blessy Babu Adeeb M. Narangoli Pablo G. Bermejo Hanadi Al Hamad Marwan Ramadan Peter Woodruff Mark Santos Maher Saqqur Ashfaq Shuaib Rayaz A. Malik |
| author_sort |
Adnan Khan |
| title |
Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| title_short |
Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| title_full |
Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| title_fullStr |
Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| title_full_unstemmed |
Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| title_sort |
corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8e73ac56e3ec4ffc9d82de6f3c103226 |
| work_keys_str_mv |
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