Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice

Abstract Although extremely low-frequency electric fields (ELF-EF) have been utilised for therapeutic purposes, the biological effect and the underlying mechanism of ELF-EF have not been elucidated. Here, we developed a mouse model of immobilisation-induced increase in glucocorticoid (GC) to evaluat...

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Autores principales:	Shinji Harakawa, Takaki Nedachi, Hiroshi Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e75a108dfa84601a9e57e74cffb397e
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spelling	oai:doaj.org-article:8e75a108dfa84601a9e57e74cffb397e2021-12-02T11:42:13ZExtremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice10.1038/s41598-020-76106-12045-2322https://doaj.org/article/8e75a108dfa84601a9e57e74cffb397e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76106-1https://doaj.org/toc/2045-2322Abstract Although extremely low-frequency electric fields (ELF-EF) have been utilised for therapeutic purposes, the biological effect and the underlying mechanism of ELF-EF have not been elucidated. Here, we developed a mouse model of immobilisation-induced increase in glucocorticoid (GC) to evaluate the effect of ELF-EF. Mice were exposed to 50-Hz 10 kV/m EF via a parallel plate electrode and immobilised as needed. The ELF-EF suppressed the immobilisation-induced increase in blood GC level. Here, the results of 32 tests using the model were pooled and analysed. The suppressive effect of ELF-EF on immobilisation-induced increase in GC was reproduced, and the GC level was slightly higher in the ELF-EF-treated mice than in the sham-controlled mice, a novel observation. The immobilisation-induced increase in lactate dehydrogenase, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase, markers of tissue damage, was suppressed by co-treatment with EF in the biochemical tests using the same plasma sample. In the metabolome analysis, the changes in corticosterones, leukotrienes, and hydroxyeicosatetraenoic acids, markers of inflammation, showed a pattern similar to that of the plasma GC level. Thus, ELF-EF suppresses the stress response that causes an increase in the GC level and slightly promotes GC production in the absence of stress. Moreover, the suppressive effect of ELF-EF on induced stress response might be involved in stress-induced tissue damage or inflammation in immobilised mice. Overall, the model and the data help explore the biological effect of ELF-EF and explain the stress-relieving effect of EF. They would be useful in determining the medical applications of EF in humans and animals.Shinji HarakawaTakaki NedachiHiroshi SuzukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shinji Harakawa Takaki Nedachi Hiroshi Suzuki Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
description	Abstract Although extremely low-frequency electric fields (ELF-EF) have been utilised for therapeutic purposes, the biological effect and the underlying mechanism of ELF-EF have not been elucidated. Here, we developed a mouse model of immobilisation-induced increase in glucocorticoid (GC) to evaluate the effect of ELF-EF. Mice were exposed to 50-Hz 10 kV/m EF via a parallel plate electrode and immobilised as needed. The ELF-EF suppressed the immobilisation-induced increase in blood GC level. Here, the results of 32 tests using the model were pooled and analysed. The suppressive effect of ELF-EF on immobilisation-induced increase in GC was reproduced, and the GC level was slightly higher in the ELF-EF-treated mice than in the sham-controlled mice, a novel observation. The immobilisation-induced increase in lactate dehydrogenase, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase, markers of tissue damage, was suppressed by co-treatment with EF in the biochemical tests using the same plasma sample. In the metabolome analysis, the changes in corticosterones, leukotrienes, and hydroxyeicosatetraenoic acids, markers of inflammation, showed a pattern similar to that of the plasma GC level. Thus, ELF-EF suppresses the stress response that causes an increase in the GC level and slightly promotes GC production in the absence of stress. Moreover, the suppressive effect of ELF-EF on induced stress response might be involved in stress-induced tissue damage or inflammation in immobilised mice. Overall, the model and the data help explore the biological effect of ELF-EF and explain the stress-relieving effect of EF. They would be useful in determining the medical applications of EF in humans and animals.
format	article
author	Shinji Harakawa Takaki Nedachi Hiroshi Suzuki
author_facet	Shinji Harakawa Takaki Nedachi Hiroshi Suzuki
author_sort	Shinji Harakawa
title	Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
title_short	Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
title_full	Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
title_fullStr	Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
title_full_unstemmed	Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
title_sort	extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8e75a108dfa84601a9e57e74cffb397e
work_keys_str_mv	AT shinjiharakawa extremelylowfrequencyelectricfieldsuppressesnotonlyinducedstressresponsebutalsostressrelatedtissuedamageinmice AT takakinedachi extremelylowfrequencyelectricfieldsuppressesnotonlyinducedstressresponsebutalsostressrelatedtissuedamageinmice AT hiroshisuzuki extremelylowfrequencyelectricfieldsuppressesnotonlyinducedstressresponsebutalsostressrelatedtissuedamageinmice
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Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice

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