Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization

Abstract The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose...

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Autores principales:	Hiroki Sugiyama, Kaneto Tsunemitsu, Hiroaki Onoe, Kotaro Obata, Koji Sugioka, Mitsuhiro Terakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e788dfb178c435ab418abd6b7fdae18
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spelling	oai:doaj.org-article:8e788dfb178c435ab418abd6b7fdae182021-12-02T16:53:11ZMicrofabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization10.1038/s41598-021-90445-72045-2322https://doaj.org/article/8e788dfb178c435ab418abd6b7fdae182021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90445-7https://doaj.org/toc/2045-2322Abstract The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose nanofibers (CNFs) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels by multiphoton polymerization. The stress of the fabricated microstructure during tensile testing increased with an increase in the CNF concentration, indicating that the mechanical strength of the microstructure was enhanced by using CNFs as fillers. Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel. Our results show the potential of the technique for the microfabrication of advanced cell scaffolds and soft microrobots with the desired mechanical strength.Hiroki SugiyamaKaneto TsunemitsuHiroaki OnoeKotaro ObataKoji SugiokaMitsuhiro TerakawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroki Sugiyama Kaneto Tsunemitsu Hiroaki Onoe Kotaro Obata Koji Sugioka Mitsuhiro Terakawa Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
description	Abstract The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose nanofibers (CNFs) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels by multiphoton polymerization. The stress of the fabricated microstructure during tensile testing increased with an increase in the CNF concentration, indicating that the mechanical strength of the microstructure was enhanced by using CNFs as fillers. Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel. Our results show the potential of the technique for the microfabrication of advanced cell scaffolds and soft microrobots with the desired mechanical strength.
format	article
author	Hiroki Sugiyama Kaneto Tsunemitsu Hiroaki Onoe Kotaro Obata Koji Sugioka Mitsuhiro Terakawa
author_facet	Hiroki Sugiyama Kaneto Tsunemitsu Hiroaki Onoe Kotaro Obata Koji Sugioka Mitsuhiro Terakawa
author_sort	Hiroki Sugiyama
title	Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
title_short	Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
title_full	Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
title_fullStr	Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
title_full_unstemmed	Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
title_sort	microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e788dfb178c435ab418abd6b7fdae18
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Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization

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