Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal

In 2011, phthalates, mainly di-(2-ethylhexyl) phthalate (DEHP), were found to have been added to a variety of foods in Taiwan, increasing the risk of microalbuminuria in children. Exposure to melamine perhaps modifies that risk. This prospective cohort study investigates whether renal injury resulti...

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Autores principales:	Hui-Ju Tsai, Chia-Fang Wu, Chao A. Hsiung, Chieng-Hung Lee, Shu-Li Wang, Mei-Lien Chen, Chu-Chih Chen, Po-Chin Huang, Yin-Han Wang, Yuh-An Chen, Bai-Hsiun Chen, Yun-Shiuan Chuang, Hui-Min Hsieh, Ming-Tsang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Di-2-ethylhexyl phthalate Melamine Malondialdehyde 8-oxo-2′-deoxyguanosine Urinary albumin/creatinine ratio N-acetyl-beta-D-glucosaminidase Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/8e79b52a62f44412950d27e76ed5deb2
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spelling	oai:doaj.org-article:8e79b52a62f44412950d27e76ed5deb22021-12-04T04:32:07ZLongitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal0160-412010.1016/j.envint.2021.107018https://doaj.org/article/8e79b52a62f44412950d27e76ed5deb22022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0160412021006437https://doaj.org/toc/0160-4120In 2011, phthalates, mainly di-(2-ethylhexyl) phthalate (DEHP), were found to have been added to a variety of foods in Taiwan, increasing the risk of microalbuminuria in children. Exposure to melamine perhaps modifies that risk. This prospective cohort study investigates whether renal injury resulting from exposure to DEHP-tainted foods from the 2011 Taiwan Food Scandal is reversed over time. The temporal and interactive effects of past daily DEHP intake, current daily DEHP intake, and urinary melamine levels on oxidative stress and renal injury were also examined.Two hundred possibly DEHP-affected children (aged < 18 years) were enrolled in the first survey wave (August 2012–January 2013), with 170 and 159 children in the second (July 2014–February 2015) and third waves (May 2016–October 2016), respectively. The first wave comprised questionnaires that were used to collect information about possible past daily DEHP intake from DEHP-tainted foods. One-spot first morning urine samples were collected to measure melamine levels, phthalate metabolites, and markers indicating oxidative stress (malondialdehyde and 8-oxo-2′-deoxyguanosine), and renal injury (albumin/creatinine ratio (ACR) and N-acetyl-beta-D-glucosaminidase) in all three waves. Generalized estimating equation (GEE) modeling revealed that both past daily DEHP intake and time might affect urinary ACR. However, most interactions were negative and significant correlation was observed only during the second wave (P for interaction = 0.014) in the group with the highest past daily DEHP intake (>50 μg/kg/day). Urinary melamine levels were found to correlate significantly with both urinary ACR and oxidative stress markers. The highest impact associated with exposure to DEHP-tainted foods in increasing urinary ACR of children was observed during the first wave, and the effect may partially diminish over time. These results suggest that continuous monitoring of renal health and other long-term health consequences is required in individuals who were affected by the scandal in 2011.Hui-Ju TsaiChia-Fang WuChao A. HsiungChieng-Hung LeeShu-Li WangMei-Lien ChenChu-Chih ChenPo-Chin HuangYin-Han WangYuh-An ChenBai-Hsiun ChenYun-Shiuan ChuangHui-Min HsiehMing-Tsang WuElsevierarticleDi-2-ethylhexyl phthalateMelamineMalondialdehyde8-oxo-2′-deoxyguanosineUrinary albumin/creatinine ratioN-acetyl-beta-D-glucosaminidaseEnvironmental sciencesGE1-350ENEnvironment International, Vol 158, Iss , Pp 107018- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Di-2-ethylhexyl phthalate Melamine Malondialdehyde 8-oxo-2′-deoxyguanosine Urinary albumin/creatinine ratio N-acetyl-beta-D-glucosaminidase Environmental sciences GE1-350
spellingShingle	Di-2-ethylhexyl phthalate Melamine Malondialdehyde 8-oxo-2′-deoxyguanosine Urinary albumin/creatinine ratio N-acetyl-beta-D-glucosaminidase Environmental sciences GE1-350 Hui-Ju Tsai Chia-Fang Wu Chao A. Hsiung Chieng-Hung Lee Shu-Li Wang Mei-Lien Chen Chu-Chih Chen Po-Chin Huang Yin-Han Wang Yuh-An Chen Bai-Hsiun Chen Yun-Shiuan Chuang Hui-Min Hsieh Ming-Tsang Wu Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal
description	In 2011, phthalates, mainly di-(2-ethylhexyl) phthalate (DEHP), were found to have been added to a variety of foods in Taiwan, increasing the risk of microalbuminuria in children. Exposure to melamine perhaps modifies that risk. This prospective cohort study investigates whether renal injury resulting from exposure to DEHP-tainted foods from the 2011 Taiwan Food Scandal is reversed over time. The temporal and interactive effects of past daily DEHP intake, current daily DEHP intake, and urinary melamine levels on oxidative stress and renal injury were also examined.Two hundred possibly DEHP-affected children (aged < 18 years) were enrolled in the first survey wave (August 2012–January 2013), with 170 and 159 children in the second (July 2014–February 2015) and third waves (May 2016–October 2016), respectively. The first wave comprised questionnaires that were used to collect information about possible past daily DEHP intake from DEHP-tainted foods. One-spot first morning urine samples were collected to measure melamine levels, phthalate metabolites, and markers indicating oxidative stress (malondialdehyde and 8-oxo-2′-deoxyguanosine), and renal injury (albumin/creatinine ratio (ACR) and N-acetyl-beta-D-glucosaminidase) in all three waves. Generalized estimating equation (GEE) modeling revealed that both past daily DEHP intake and time might affect urinary ACR. However, most interactions were negative and significant correlation was observed only during the second wave (P for interaction = 0.014) in the group with the highest past daily DEHP intake (>50 μg/kg/day). Urinary melamine levels were found to correlate significantly with both urinary ACR and oxidative stress markers. The highest impact associated with exposure to DEHP-tainted foods in increasing urinary ACR of children was observed during the first wave, and the effect may partially diminish over time. These results suggest that continuous monitoring of renal health and other long-term health consequences is required in individuals who were affected by the scandal in 2011.
format	article
author	Hui-Ju Tsai Chia-Fang Wu Chao A. Hsiung Chieng-Hung Lee Shu-Li Wang Mei-Lien Chen Chu-Chih Chen Po-Chin Huang Yin-Han Wang Yuh-An Chen Bai-Hsiun Chen Yun-Shiuan Chuang Hui-Min Hsieh Ming-Tsang Wu
author_facet	Hui-Ju Tsai Chia-Fang Wu Chao A. Hsiung Chieng-Hung Lee Shu-Li Wang Mei-Lien Chen Chu-Chih Chen Po-Chin Huang Yin-Han Wang Yuh-An Chen Bai-Hsiun Chen Yun-Shiuan Chuang Hui-Min Hsieh Ming-Tsang Wu
author_sort	Hui-Ju Tsai
title	Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal
title_short	Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal
title_full	Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal
title_fullStr	Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal
title_full_unstemmed	Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal
title_sort	longitudinal changes in oxidative stress and early renal injury in children exposed to dehp and melamine in the 2011 taiwan food scandal
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/8e79b52a62f44412950d27e76ed5deb2
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Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal

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