Fluid shear stress activates YAP1 to promote cancer cell motility

Fluid frictional forces around cancer cells influence chemokine production and delivery of chemotherapeutic drugs but it is unclear if they directly impact tumour biology through biomechanical effects. Here, the authors show that wall shear stress stimulates cancer cell migration through a ROCK–LIMK...

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Autores principales:	Hyun Jung Lee, Miguel F. Diaz, Katherine M. Price, Joyce A. Ozuna, Songlin Zhang, Eva M. Sevick-Muraca, John P. Hagan, Pamela L. Wenzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8e8007f0521c4fb5861ef0ff47661f28
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spelling	oai:doaj.org-article:8e8007f0521c4fb5861ef0ff47661f282021-12-02T15:38:59ZFluid shear stress activates YAP1 to promote cancer cell motility10.1038/ncomms141222041-1723https://doaj.org/article/8e8007f0521c4fb5861ef0ff47661f282017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14122https://doaj.org/toc/2041-1723Fluid frictional forces around cancer cells influence chemokine production and delivery of chemotherapeutic drugs but it is unclear if they directly impact tumour biology through biomechanical effects. Here, the authors show that wall shear stress stimulates cancer cell migration through a ROCK–LIMK–YAP axis.Hyun Jung LeeMiguel F. DiazKatherine M. PriceJoyce A. OzunaSonglin ZhangEva M. Sevick-MuracaJohn P. HaganPamela L. WenzelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyun Jung Lee Miguel F. Diaz Katherine M. Price Joyce A. Ozuna Songlin Zhang Eva M. Sevick-Muraca John P. Hagan Pamela L. Wenzel Fluid shear stress activates YAP1 to promote cancer cell motility
description	Fluid frictional forces around cancer cells influence chemokine production and delivery of chemotherapeutic drugs but it is unclear if they directly impact tumour biology through biomechanical effects. Here, the authors show that wall shear stress stimulates cancer cell migration through a ROCK–LIMK–YAP axis.
format	article
author	Hyun Jung Lee Miguel F. Diaz Katherine M. Price Joyce A. Ozuna Songlin Zhang Eva M. Sevick-Muraca John P. Hagan Pamela L. Wenzel
author_facet	Hyun Jung Lee Miguel F. Diaz Katherine M. Price Joyce A. Ozuna Songlin Zhang Eva M. Sevick-Muraca John P. Hagan Pamela L. Wenzel
author_sort	Hyun Jung Lee
title	Fluid shear stress activates YAP1 to promote cancer cell motility
title_short	Fluid shear stress activates YAP1 to promote cancer cell motility
title_full	Fluid shear stress activates YAP1 to promote cancer cell motility
title_fullStr	Fluid shear stress activates YAP1 to promote cancer cell motility
title_full_unstemmed	Fluid shear stress activates YAP1 to promote cancer cell motility
title_sort	fluid shear stress activates yap1 to promote cancer cell motility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8e8007f0521c4fb5861ef0ff47661f28
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Fluid shear stress activates YAP1 to promote cancer cell motility

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