Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies

Functional disability due to spatial neglect hinders recovery in up to 30% of stroke survivors. Prism adaptation treatment (PAT) may alleviate the disabling consequences of spatial neglect, but we do not yet know why some individuals show much better outcomes following PAT than others. The goal of t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olga Boukrina, Peii Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spatial neglect hemi-spatial neglect stroke fMRI attention prism adaptation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/8e826a33b4db44a5931978a403d96db1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e826a33b4db44a5931978a403d96db1
record_format	dspace
spelling	oai:doaj.org-article:8e826a33b4db44a5931978a403d96db12021-11-25T16:57:56ZNeural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies10.3390/brainsci111114682076-3425https://doaj.org/article/8e826a33b4db44a5931978a403d96db12021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1468https://doaj.org/toc/2076-3425Functional disability due to spatial neglect hinders recovery in up to 30% of stroke survivors. Prism adaptation treatment (PAT) may alleviate the disabling consequences of spatial neglect, but we do not yet know why some individuals show much better outcomes following PAT than others. The goal of this scoping review and meta-analysis was to investigate the neural mechanisms underlying prism adaptation (PA). We conducted both quantitative and qualitative analyses across fMRI studies investigating brain activity before, during, and after PA, in healthy individuals and patients with right or left brain damage (RBD or LBD) due to stroke. In healthy adults, PA was linked with activity in posterior parietal and cerebellar clusters, reduced bilateral parieto-frontal connectivity, and increased fronto-limbic and sensorimotor network connectivity. In contrast, RBD individuals with spatial neglect relied on different circuits, including an activity cluster in the intact left occipital cortex. This finding is consistent with a shift in hemispheric dominance in spatial processing to the left hemisphere. However, more studies are needed to clarify the contribution of lesion location and load on the circuits involved in PA after unilateral brain damage. Future studies are also needed to clarify the relationship of decreasing resting state functional connectivity (rsFC) to visuomotor function.Olga BoukrinaPeii ChenMDPI AGarticlespatial neglecthemi-spatial neglectstrokefMRIattentionprism adaptationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1468, p 1468 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spatial neglect hemi-spatial neglect stroke fMRI attention prism adaptation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	spatial neglect hemi-spatial neglect stroke fMRI attention prism adaptation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Olga Boukrina Peii Chen Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies
description	Functional disability due to spatial neglect hinders recovery in up to 30% of stroke survivors. Prism adaptation treatment (PAT) may alleviate the disabling consequences of spatial neglect, but we do not yet know why some individuals show much better outcomes following PAT than others. The goal of this scoping review and meta-analysis was to investigate the neural mechanisms underlying prism adaptation (PA). We conducted both quantitative and qualitative analyses across fMRI studies investigating brain activity before, during, and after PA, in healthy individuals and patients with right or left brain damage (RBD or LBD) due to stroke. In healthy adults, PA was linked with activity in posterior parietal and cerebellar clusters, reduced bilateral parieto-frontal connectivity, and increased fronto-limbic and sensorimotor network connectivity. In contrast, RBD individuals with spatial neglect relied on different circuits, including an activity cluster in the intact left occipital cortex. This finding is consistent with a shift in hemispheric dominance in spatial processing to the left hemisphere. However, more studies are needed to clarify the contribution of lesion location and load on the circuits involved in PA after unilateral brain damage. Future studies are also needed to clarify the relationship of decreasing resting state functional connectivity (rsFC) to visuomotor function.
format	article
author	Olga Boukrina Peii Chen
author_facet	Olga Boukrina Peii Chen
author_sort	Olga Boukrina
title	Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies
title_short	Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies
title_full	Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies
title_fullStr	Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies
title_full_unstemmed	Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies
title_sort	neural mechanisms of prism adaptation in healthy adults and individuals with spatial neglect after unilateral stroke: a review of fmri studies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8e826a33b4db44a5931978a403d96db1
work_keys_str_mv	AT olgaboukrina neuralmechanismsofprismadaptationinhealthyadultsandindividualswithspatialneglectafterunilateralstrokeareviewoffmristudies AT peiichen neuralmechanismsofprismadaptationinhealthyadultsandindividualswithspatialneglectafterunilateralstrokeareviewoffmristudies
_version_	1718412850163089408

Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies

Ejemplares similares