Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials

Abstract Studies have suggested that hyperbaric oxygen therapy (HBOT) is effective in the healing of diabetic foot ulcer (DFU); however, there is a lack of consensus. Therefore, to assess the efficacy of HBOT on diabetic foot ulcer among diabetic patients, controlled clinical trials were searched th...

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Autores principales:	Rakesh Sharma, Suresh K. Sharma, Shiv Kumar Mudgal, Prasuna Jelly, Kalpana Thakur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e83dabac47344d9a4c9bf10215e1e7c
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spelling	oai:doaj.org-article:8e83dabac47344d9a4c9bf10215e1e7c2021-12-02T10:48:13ZEfficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials10.1038/s41598-021-81886-12045-2322https://doaj.org/article/8e83dabac47344d9a4c9bf10215e1e7c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81886-1https://doaj.org/toc/2045-2322Abstract Studies have suggested that hyperbaric oxygen therapy (HBOT) is effective in the healing of diabetic foot ulcer (DFU); however, there is a lack of consensus. Therefore, to assess the efficacy of HBOT on diabetic foot ulcer among diabetic patients, controlled clinical trials were searched through PubMed, EMBASE, Clinical key, Ovid Discovery, ERMED, Clinical Trials.gov databases for randomized controlled trials (RCTs) and other sources until 15 September 2020. Studies that evaluated the effect of HBOT on diabetic foot ulcer, complete healing, amputation, adverse events, ulcer reduction area, and mortality rate were included. Of 1984 study records screened, 14 studies (768 participants) including twelve RCTs, and two CCTs were included as per inclusion criteria. The results with pooled analysis have shown that HBOT was significantly effective in complete healing of diabetic foot ulcer (OR = 0.29; 95% CI 0.14–0.61; I2 = 62%) and reduction of major amputation (RR = 0.60; 95% CI 0.39–0.92; I2 = 24%). Although, it was not effective for minor amputations (RR = 0.82; 95% CI 0.34–1.97; I2 = 79%); however, less adverse events were reported in standard treatment group (RR = 1.68; 95% CI 1.07–2.65; I2 = 0%). Nevertheless, reduction in mean percentage of ulcer area and mortality rate did not differ in HBOT and control groups. This review provides an evidence that hyperbaric oxygen therapy is effective as an adjunct treatment measure for the diabetes foot ulcers. These findings could be generalized cautiously by considering methodological flaws within all studies.Rakesh SharmaSuresh K. SharmaShiv Kumar MudgalPrasuna JellyKalpana ThakurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rakesh Sharma Suresh K. Sharma Shiv Kumar Mudgal Prasuna Jelly Kalpana Thakur Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
description	Abstract Studies have suggested that hyperbaric oxygen therapy (HBOT) is effective in the healing of diabetic foot ulcer (DFU); however, there is a lack of consensus. Therefore, to assess the efficacy of HBOT on diabetic foot ulcer among diabetic patients, controlled clinical trials were searched through PubMed, EMBASE, Clinical key, Ovid Discovery, ERMED, Clinical Trials.gov databases for randomized controlled trials (RCTs) and other sources until 15 September 2020. Studies that evaluated the effect of HBOT on diabetic foot ulcer, complete healing, amputation, adverse events, ulcer reduction area, and mortality rate were included. Of 1984 study records screened, 14 studies (768 participants) including twelve RCTs, and two CCTs were included as per inclusion criteria. The results with pooled analysis have shown that HBOT was significantly effective in complete healing of diabetic foot ulcer (OR = 0.29; 95% CI 0.14–0.61; I2 = 62%) and reduction of major amputation (RR = 0.60; 95% CI 0.39–0.92; I2 = 24%). Although, it was not effective for minor amputations (RR = 0.82; 95% CI 0.34–1.97; I2 = 79%); however, less adverse events were reported in standard treatment group (RR = 1.68; 95% CI 1.07–2.65; I2 = 0%). Nevertheless, reduction in mean percentage of ulcer area and mortality rate did not differ in HBOT and control groups. This review provides an evidence that hyperbaric oxygen therapy is effective as an adjunct treatment measure for the diabetes foot ulcers. These findings could be generalized cautiously by considering methodological flaws within all studies.
format	article
author	Rakesh Sharma Suresh K. Sharma Shiv Kumar Mudgal Prasuna Jelly Kalpana Thakur
author_facet	Rakesh Sharma Suresh K. Sharma Shiv Kumar Mudgal Prasuna Jelly Kalpana Thakur
author_sort	Rakesh Sharma
title	Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
title_short	Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
title_full	Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
title_fullStr	Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
title_full_unstemmed	Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
title_sort	efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e83dabac47344d9a4c9bf10215e1e7c
work_keys_str_mv	AT rakeshsharma efficacyofhyperbaricoxygentherapyfordiabeticfootulcerasystematicreviewandmetaanalysisofcontrolledclinicaltrials AT sureshksharma efficacyofhyperbaricoxygentherapyfordiabeticfootulcerasystematicreviewandmetaanalysisofcontrolledclinicaltrials AT shivkumarmudgal efficacyofhyperbaricoxygentherapyfordiabeticfootulcerasystematicreviewandmetaanalysisofcontrolledclinicaltrials AT prasunajelly efficacyofhyperbaricoxygentherapyfordiabeticfootulcerasystematicreviewandmetaanalysisofcontrolledclinicaltrials AT kalpanathakur efficacyofhyperbaricoxygentherapyfordiabeticfootulcerasystematicreviewandmetaanalysisofcontrolledclinicaltrials
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Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials

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