Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

BackgroundLocal recurrence of esophageal squamous cell neoplasia (ESCN) and metachronous ESCN was associated with severe background esophageal multiple Lugol-voiding lesions (LVLs) even though the primary early ESCNs were treated with endoscopic resection (ER). The aim of this study is to explore th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhihao Chen, Lizhou Dou, Yong Liu, Yueming Zhang, Shun He, Liyan Xue, Guiqi Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	endoscopic resection radiofrequency ablation multiple Lugol-voiding lesions esophageal squamous cell neoplasia background esophageal mucosa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8e87a8361ad14caa960092857df9da05
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e87a8361ad14caa960092857df9da05
record_format	dspace
spelling	oai:doaj.org-article:8e87a8361ad14caa960092857df9da052021-11-30T15:57:36ZCombination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions2234-943X10.3389/fonc.2021.786015https://doaj.org/article/8e87a8361ad14caa960092857df9da052021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.786015/fullhttps://doaj.org/toc/2234-943XBackgroundLocal recurrence of esophageal squamous cell neoplasia (ESCN) and metachronous ESCN was associated with severe background esophageal multiple Lugol-voiding lesions (LVLs) even though the primary early ESCNs were treated with endoscopic resection (ER). The aim of this study is to explore the feasibility and effectiveness of combination treatments of ER and radiofrequency ablation (RFA) in patients with early ESCNs with synchronous multiple LVLs.MethodsA total of 329 patients with early ESCNs and synchronous multiple LVLs received ER combined with RFA from September 2010 to September 2020. Clinical and pathological features and treatment outcomes were retrospectively reviewed using medical records. Factors associated with background esophageal multiple LVLs before combined treatment were analyzed.ResultsThe proportion of complete response (CR) was 96.7% after primary RFA, while 90.3% patients achieved CR for the last endoscopic examinations regardless if inside or outside the treatment area (TA). Degeneration of background esophageal multiple LVLs occurred in 70.2% of patients. The grade of background esophageal multiple LVLs before combined treatment was closely related to gender, smoking, and drinking. The incidence of metachronous ESCNs outside the TA of ER and local recurrence in the TA of ER was 3.9% and 1.2%, respectively.ConclusionsProphylactic RFA treatment of multiple LVLs together with ER treatment of the primary ESCNs may be effective in reducing the incidence of metachronous ESCNs and local recurrence through improving the background esophageal mucosa.Zhihao ChenLizhou DouYong LiuYueming ZhangShun HeLiyan XueGuiqi WangFrontiers Media S.A.articleendoscopic resectionradiofrequency ablationmultiple Lugol-voiding lesionsesophageal squamous cell neoplasiabackground esophageal mucosaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endoscopic resection radiofrequency ablation multiple Lugol-voiding lesions esophageal squamous cell neoplasia background esophageal mucosa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	endoscopic resection radiofrequency ablation multiple Lugol-voiding lesions esophageal squamous cell neoplasia background esophageal mucosa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhihao Chen Lizhou Dou Yong Liu Yueming Zhang Shun He Liyan Xue Guiqi Wang Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
description	BackgroundLocal recurrence of esophageal squamous cell neoplasia (ESCN) and metachronous ESCN was associated with severe background esophageal multiple Lugol-voiding lesions (LVLs) even though the primary early ESCNs were treated with endoscopic resection (ER). The aim of this study is to explore the feasibility and effectiveness of combination treatments of ER and radiofrequency ablation (RFA) in patients with early ESCNs with synchronous multiple LVLs.MethodsA total of 329 patients with early ESCNs and synchronous multiple LVLs received ER combined with RFA from September 2010 to September 2020. Clinical and pathological features and treatment outcomes were retrospectively reviewed using medical records. Factors associated with background esophageal multiple LVLs before combined treatment were analyzed.ResultsThe proportion of complete response (CR) was 96.7% after primary RFA, while 90.3% patients achieved CR for the last endoscopic examinations regardless if inside or outside the treatment area (TA). Degeneration of background esophageal multiple LVLs occurred in 70.2% of patients. The grade of background esophageal multiple LVLs before combined treatment was closely related to gender, smoking, and drinking. The incidence of metachronous ESCNs outside the TA of ER and local recurrence in the TA of ER was 3.9% and 1.2%, respectively.ConclusionsProphylactic RFA treatment of multiple LVLs together with ER treatment of the primary ESCNs may be effective in reducing the incidence of metachronous ESCNs and local recurrence through improving the background esophageal mucosa.
format	article
author	Zhihao Chen Lizhou Dou Yong Liu Yueming Zhang Shun He Liyan Xue Guiqi Wang
author_facet	Zhihao Chen Lizhou Dou Yong Liu Yueming Zhang Shun He Liyan Xue Guiqi Wang
author_sort	Zhihao Chen
title	Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
title_short	Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
title_full	Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
title_fullStr	Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
title_full_unstemmed	Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
title_sort	combination of endoscopic resection and radiofrequency ablation for the treatment of esophageal squamous cell neoplasia with multiple lugol-voiding lesions
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8e87a8361ad14caa960092857df9da05
work_keys_str_mv	AT zhihaochen combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions AT lizhoudou combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions AT yongliu combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions AT yuemingzhang combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions AT shunhe combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions AT liyanxue combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions AT guiqiwang combinationofendoscopicresectionandradiofrequencyablationforthetreatmentofesophagealsquamouscellneoplasiawithmultiplelugolvoidinglesions
_version_	1718406517334474752

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions

Ejemplares similares