Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.

<h4>Background</h4>Oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) in more than 95% of patients with multiple sclerosis (MS) in the Western hemisphere. Here we evaluated the intrathecal, polyspecific antiviral immune response as a potential diagnostic CSF marker for...

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Autores principales:	Isabel Brecht, Benedikt Weissbrich, Julia Braun, Klaus Viktor Toyka, Andreas Weishaupt, Mathias Buttmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e8e74a90d864423b1b4ce6b5cfb5f34
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spelling	oai:doaj.org-article:8e8e74a90d864423b1b4ce6b5cfb5f342021-11-18T07:13:06ZIntrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.1932-620310.1371/journal.pone.0040431https://doaj.org/article/8e8e74a90d864423b1b4ce6b5cfb5f342012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792316/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) in more than 95% of patients with multiple sclerosis (MS) in the Western hemisphere. Here we evaluated the intrathecal, polyspecific antiviral immune response as a potential diagnostic CSF marker for OCB-negative MS patients.<h4>Methodology/principal findings</h4>We tested 46 OCB-negative German patients with paraclinically well defined, definite MS. Sixteen OCB-negative patients with a clear diagnosis of other autoimmune CNS disorders and 37 neurological patients without evidence for autoimmune CNS inflammation served as control groups. Antibodies against measles, rubella, varicella zoster and herpes simplex virus in paired serum and CSF samples were determined by ELISA, and virus-specific immunoglobulin G antibody indices were calculated. An intrathecal antibody synthesis against at least one neurotropic virus was detected in 8 of 26 (31%) patients with relapsing-remitting MS, 8 of 12 (67%) with secondary progressive MS and 5 of 8 (63%) with primary progressive MS, in 3 of 16 (19%) CNS autoimmune and 3 of 37 (8%) non-autoimmune control patients. Antibody synthesis against two or more viruses was found in 11 of 46 (24%) MS patients but in neither of the two control groups. On average, MS patients with a positive antiviral immune response were older and had a longer disease duration than those without.<h4>Conclusion</h4>Determination of the intrathecal, polyspecific antiviral immune response may allow to establish a CSF-supported diagnosis of MS in OCB-negative patients when two or more of the four virus antibody indices are elevated.Isabel BrechtBenedikt WeissbrichJulia BraunKlaus Viktor ToykaAndreas WeishauptMathias ButtmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40431 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabel Brecht Benedikt Weissbrich Julia Braun Klaus Viktor Toyka Andreas Weishaupt Mathias Buttmann Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
description	<h4>Background</h4>Oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) in more than 95% of patients with multiple sclerosis (MS) in the Western hemisphere. Here we evaluated the intrathecal, polyspecific antiviral immune response as a potential diagnostic CSF marker for OCB-negative MS patients.<h4>Methodology/principal findings</h4>We tested 46 OCB-negative German patients with paraclinically well defined, definite MS. Sixteen OCB-negative patients with a clear diagnosis of other autoimmune CNS disorders and 37 neurological patients without evidence for autoimmune CNS inflammation served as control groups. Antibodies against measles, rubella, varicella zoster and herpes simplex virus in paired serum and CSF samples were determined by ELISA, and virus-specific immunoglobulin G antibody indices were calculated. An intrathecal antibody synthesis against at least one neurotropic virus was detected in 8 of 26 (31%) patients with relapsing-remitting MS, 8 of 12 (67%) with secondary progressive MS and 5 of 8 (63%) with primary progressive MS, in 3 of 16 (19%) CNS autoimmune and 3 of 37 (8%) non-autoimmune control patients. Antibody synthesis against two or more viruses was found in 11 of 46 (24%) MS patients but in neither of the two control groups. On average, MS patients with a positive antiviral immune response were older and had a longer disease duration than those without.<h4>Conclusion</h4>Determination of the intrathecal, polyspecific antiviral immune response may allow to establish a CSF-supported diagnosis of MS in OCB-negative patients when two or more of the four virus antibody indices are elevated.
format	article
author	Isabel Brecht Benedikt Weissbrich Julia Braun Klaus Viktor Toyka Andreas Weishaupt Mathias Buttmann
author_facet	Isabel Brecht Benedikt Weissbrich Julia Braun Klaus Viktor Toyka Andreas Weishaupt Mathias Buttmann
author_sort	Isabel Brecht
title	Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
title_short	Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
title_full	Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
title_fullStr	Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
title_full_unstemmed	Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
title_sort	intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8e8e74a90d864423b1b4ce6b5cfb5f34
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Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.

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