Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation.
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Nature Portfolio
2018
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oai:doaj.org-article:8e8eefa46f644e3e88874424709de09f2021-12-02T17:31:59ZOxidation of Atg3 and Atg7 mediates inhibition of autophagy10.1038/s41467-017-02352-z2041-1723https://doaj.org/article/8e8eefa46f644e3e88874424709de09f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02352-zhttps://doaj.org/toc/2041-1723A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation.Karen FruddThomas BurgoyneJoseph Robert BurgoyneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Karen Frudd Thomas Burgoyne Joseph Robert Burgoyne Oxidation of Atg3 and Atg7 mediates inhibition of autophagy |
description |
A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation. |
format |
article |
author |
Karen Frudd Thomas Burgoyne Joseph Robert Burgoyne |
author_facet |
Karen Frudd Thomas Burgoyne Joseph Robert Burgoyne |
author_sort |
Karen Frudd |
title |
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy |
title_short |
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy |
title_full |
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy |
title_fullStr |
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy |
title_full_unstemmed |
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy |
title_sort |
oxidation of atg3 and atg7 mediates inhibition of autophagy |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/8e8eefa46f644e3e88874424709de09f |
work_keys_str_mv |
AT karenfrudd oxidationofatg3andatg7mediatesinhibitionofautophagy AT thomasburgoyne oxidationofatg3andatg7mediatesinhibitionofautophagy AT josephrobertburgoyne oxidationofatg3andatg7mediatesinhibitionofautophagy |
_version_ |
1718380441798443008 |