Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation.

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Autores principales: Karen Frudd, Thomas Burgoyne, Joseph Robert Burgoyne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8e8eefa46f644e3e88874424709de09f
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spelling oai:doaj.org-article:8e8eefa46f644e3e88874424709de09f2021-12-02T17:31:59ZOxidation of Atg3 and Atg7 mediates inhibition of autophagy10.1038/s41467-017-02352-z2041-1723https://doaj.org/article/8e8eefa46f644e3e88874424709de09f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02352-zhttps://doaj.org/toc/2041-1723A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation.Karen FruddThomas BurgoyneJoseph Robert BurgoyneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Karen Frudd
Thomas Burgoyne
Joseph Robert Burgoyne
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
description A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation.
format article
author Karen Frudd
Thomas Burgoyne
Joseph Robert Burgoyne
author_facet Karen Frudd
Thomas Burgoyne
Joseph Robert Burgoyne
author_sort Karen Frudd
title Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
title_short Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
title_full Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
title_fullStr Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
title_full_unstemmed Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
title_sort oxidation of atg3 and atg7 mediates inhibition of autophagy
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8e8eefa46f644e3e88874424709de09f
work_keys_str_mv AT karenfrudd oxidationofatg3andatg7mediatesinhibitionofautophagy
AT thomasburgoyne oxidationofatg3andatg7mediatesinhibitionofautophagy
AT josephrobertburgoyne oxidationofatg3andatg7mediatesinhibitionofautophagy
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