Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia.
Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n = 271) or BPD (n...
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2012
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oai:doaj.org-article:8e97dfc6da974c36939c62d3d4292b6b2021-11-18T07:22:51ZProgranulin gene variability and plasma levels in bipolar disorder and schizophrenia.1932-620310.1371/journal.pone.0032164https://doaj.org/article/8e97dfc6da974c36939c62d3d4292b6b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22505994/?tool=EBIhttps://doaj.org/toc/1932-6203Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n = 271) or BPD (n = 237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls.A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P<0.001, OR:0.63, 95%CI:0.49-0.80), rs4792938 (30.7 versus 39.7%, P = 0.005, OR: 0.70, 95%CI: 0.55-0.89) and rs5848 (30.3 versus 36.8, P = 0.007, OR: 0.71, 95%CI: 0.56-0.91). Mean±SEM progranulin plasma levels were significantly decreased in BPD patients, either Germans or Italians, as compared with controls (89.69±3.97 and 116.14±5.80 ng/ml, respectively, versus 180.81±18.39 ng/ml P<0.001) and were not correlated with age.In conclusion, GRN variability decreases the risk to develop BPD and schizophrenia, and progranulin plasma levels are significantly lower in BPD patients than in controls. Nevertheless, a larger replication analysis would be needed to confirm these preliminary results.Daniela GalimbertiBernardo Dell'OssoChiara FenoglioChiara VillaFrancesca CortiniMaria SerpenteSarah Kittel-SchneiderJohannes WeiglMaria NeunerJuliane VolkertC LeonhardDavid G OlmesJuliane KopfClaudia CantoniElisa RidolfiCarlotta PalazzoLaura GhezziNereo BresolinA C AltamuraElio ScarpiniAndreas ReifPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e32164 (2012) |
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Medicine R Science Q Daniela Galimberti Bernardo Dell'Osso Chiara Fenoglio Chiara Villa Francesca Cortini Maria Serpente Sarah Kittel-Schneider Johannes Weigl Maria Neuner Juliane Volkert C Leonhard David G Olmes Juliane Kopf Claudia Cantoni Elisa Ridolfi Carlotta Palazzo Laura Ghezzi Nereo Bresolin A C Altamura Elio Scarpini Andreas Reif Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| description |
Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n = 271) or BPD (n = 237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls.A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P<0.001, OR:0.63, 95%CI:0.49-0.80), rs4792938 (30.7 versus 39.7%, P = 0.005, OR: 0.70, 95%CI: 0.55-0.89) and rs5848 (30.3 versus 36.8, P = 0.007, OR: 0.71, 95%CI: 0.56-0.91). Mean±SEM progranulin plasma levels were significantly decreased in BPD patients, either Germans or Italians, as compared with controls (89.69±3.97 and 116.14±5.80 ng/ml, respectively, versus 180.81±18.39 ng/ml P<0.001) and were not correlated with age.In conclusion, GRN variability decreases the risk to develop BPD and schizophrenia, and progranulin plasma levels are significantly lower in BPD patients than in controls. Nevertheless, a larger replication analysis would be needed to confirm these preliminary results. |
| format |
article |
| author |
Daniela Galimberti Bernardo Dell'Osso Chiara Fenoglio Chiara Villa Francesca Cortini Maria Serpente Sarah Kittel-Schneider Johannes Weigl Maria Neuner Juliane Volkert C Leonhard David G Olmes Juliane Kopf Claudia Cantoni Elisa Ridolfi Carlotta Palazzo Laura Ghezzi Nereo Bresolin A C Altamura Elio Scarpini Andreas Reif |
| author_facet |
Daniela Galimberti Bernardo Dell'Osso Chiara Fenoglio Chiara Villa Francesca Cortini Maria Serpente Sarah Kittel-Schneider Johannes Weigl Maria Neuner Juliane Volkert C Leonhard David G Olmes Juliane Kopf Claudia Cantoni Elisa Ridolfi Carlotta Palazzo Laura Ghezzi Nereo Bresolin A C Altamura Elio Scarpini Andreas Reif |
| author_sort |
Daniela Galimberti |
| title |
Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| title_short |
Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| title_full |
Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| title_fullStr |
Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| title_full_unstemmed |
Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| title_sort |
progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/8e97dfc6da974c36939c62d3d4292b6b |
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