An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.

Meiosis is a defining feature of eukaryotes but its phylogenetic distribution has not been broadly determined, especially among eukaryotic microorganisms (i.e. protists)-which represent the majority of eukaryotic 'supergroups'. We surveyed genomes of animals, fungi, plants and protists for...

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Autores principales:	Shehre-Banoo Malik, Arthur W Pightling, Lauren M Stefaniak, Andrew M Schurko, John M Logsdon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e9b2dbdb2604fb0945e766cfbd64158
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spelling	oai:doaj.org-article:8e9b2dbdb2604fb0945e766cfbd641582021-11-25T06:13:52ZAn expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.1932-620310.1371/journal.pone.0002879https://doaj.org/article/8e9b2dbdb2604fb0945e766cfbd641582007-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18663385/?tool=EBIhttps://doaj.org/toc/1932-6203Meiosis is a defining feature of eukaryotes but its phylogenetic distribution has not been broadly determined, especially among eukaryotic microorganisms (i.e. protists)-which represent the majority of eukaryotic 'supergroups'. We surveyed genomes of animals, fungi, plants and protists for meiotic genes, focusing on the evolutionarily divergent parasitic protist Trichomonas vaginalis. We identified homologs of 29 components of the meiotic recombination machinery, as well as the synaptonemal and meiotic sister chromatid cohesion complexes. T. vaginalis has orthologs of 27 of 29 meiotic genes, including eight of nine genes that encode meiosis-specific proteins in model organisms. Although meiosis has not been observed in T. vaginalis, our findings suggest it is either currently sexual or a recent asexual, consistent with observed, albeit unusual, sexual cycles in their distant parabasalid relatives, the hypermastigotes. T. vaginalis may use meiotic gene homologs to mediate homologous recombination and genetic exchange. Overall, this expanded inventory of meiotic genes forms a useful "meiosis detection toolkit". Our analyses indicate that these meiotic genes arose, or were already present, early in eukaryotic evolution; thus, the eukaryotic cenancestor contained most or all components of this set and was likely capable of performing meiotic recombination using near-universal meiotic machinery.Shehre-Banoo MalikArthur W PightlingLauren M StefaniakAndrew M SchurkoJohn M LogsdonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 8, p e2879 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shehre-Banoo Malik Arthur W Pightling Lauren M Stefaniak Andrew M Schurko John M Logsdon An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.
description	Meiosis is a defining feature of eukaryotes but its phylogenetic distribution has not been broadly determined, especially among eukaryotic microorganisms (i.e. protists)-which represent the majority of eukaryotic 'supergroups'. We surveyed genomes of animals, fungi, plants and protists for meiotic genes, focusing on the evolutionarily divergent parasitic protist Trichomonas vaginalis. We identified homologs of 29 components of the meiotic recombination machinery, as well as the synaptonemal and meiotic sister chromatid cohesion complexes. T. vaginalis has orthologs of 27 of 29 meiotic genes, including eight of nine genes that encode meiosis-specific proteins in model organisms. Although meiosis has not been observed in T. vaginalis, our findings suggest it is either currently sexual or a recent asexual, consistent with observed, albeit unusual, sexual cycles in their distant parabasalid relatives, the hypermastigotes. T. vaginalis may use meiotic gene homologs to mediate homologous recombination and genetic exchange. Overall, this expanded inventory of meiotic genes forms a useful "meiosis detection toolkit". Our analyses indicate that these meiotic genes arose, or were already present, early in eukaryotic evolution; thus, the eukaryotic cenancestor contained most or all components of this set and was likely capable of performing meiotic recombination using near-universal meiotic machinery.
format	article
author	Shehre-Banoo Malik Arthur W Pightling Lauren M Stefaniak Andrew M Schurko John M Logsdon
author_facet	Shehre-Banoo Malik Arthur W Pightling Lauren M Stefaniak Andrew M Schurko John M Logsdon
author_sort	Shehre-Banoo Malik
title	An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.
title_short	An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.
title_full	An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.
title_fullStr	An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.
title_full_unstemmed	An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.
title_sort	expanded inventory of conserved meiotic genes provides evidence for sex in trichomonas vaginalis.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/8e9b2dbdb2604fb0945e766cfbd64158
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An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.

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