Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections

Junyan Zhang,1 Mian Wang,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Background: Many cancer patients suffer from cancer-related life-thr...

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Autores principales:	Zhang J, Wang M, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	silver-coated gold nanorods anti-microbial cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8e9c7611dc8c440b87c0865e4ac380b8
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spelling	oai:doaj.org-article:8e9c7611dc8c440b87c0865e4ac380b82021-12-02T01:48:36ZSilver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections1178-2013https://doaj.org/article/8e9c7611dc8c440b87c0865e4ac380b82018-10-01T00:00:00Zhttps://www.dovepress.com/silver-coated-gold-nanorods-as-a-promising-antimicrobial-agent-in-the--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Junyan Zhang,1 Mian Wang,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Background: Many cancer patients suffer from cancer-related life-threatening infections due to immune system damage. Therefore, researchers are continuously looking for new options to treat cancer-related infections. As nanotechnology has gained tremendous interest over the past several decades, silver nanoparticles have been investigated as an effective antimicrobial agent. Here, silver-coated gold nanorods were synthesized to share similar optical properties as gold nanoparticles for cancer diagnosis and treatment, with an added advantage of antibacterial properties. Results: Their dose-dependent antimicrobial properties were demonstrated on both Gram-negative and Gram-positive bacteria species. These nanorods were found to be highly efficient in killing bacteria and suppressing biofilm formation. Conclusion: Collectively, such results suggest that silver-coated gold nanorods should be further investigated as a novel material, which can both decrease cancer cell functions and reduce the risk of infection for cancer patients. Keywords: nanotechnology, bacteria, cancer cells, infrared excitationZhang JWang MWebster TJDove Medical Pressarticlesilver-coated gold nanorodsanti-microbialcancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 6575-6583 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	silver-coated gold nanorods anti-microbial cancer Medicine (General) R5-920
spellingShingle	silver-coated gold nanorods anti-microbial cancer Medicine (General) R5-920 Zhang J Wang M Webster TJ Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
description	Junyan Zhang,1 Mian Wang,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Background: Many cancer patients suffer from cancer-related life-threatening infections due to immune system damage. Therefore, researchers are continuously looking for new options to treat cancer-related infections. As nanotechnology has gained tremendous interest over the past several decades, silver nanoparticles have been investigated as an effective antimicrobial agent. Here, silver-coated gold nanorods were synthesized to share similar optical properties as gold nanoparticles for cancer diagnosis and treatment, with an added advantage of antibacterial properties. Results: Their dose-dependent antimicrobial properties were demonstrated on both Gram-negative and Gram-positive bacteria species. These nanorods were found to be highly efficient in killing bacteria and suppressing biofilm formation. Conclusion: Collectively, such results suggest that silver-coated gold nanorods should be further investigated as a novel material, which can both decrease cancer cell functions and reduce the risk of infection for cancer patients. Keywords: nanotechnology, bacteria, cancer cells, infrared excitation
format	article
author	Zhang J Wang M Webster TJ
author_facet	Zhang J Wang M Webster TJ
author_sort	Zhang J
title	Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
title_short	Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
title_full	Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
title_fullStr	Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
title_full_unstemmed	Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
title_sort	silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/8e9c7611dc8c440b87c0865e4ac380b8
work_keys_str_mv	AT zhangj silvercoatedgoldnanorodsasapromisingantimicrobialagentinthetreatmentofcancerrelatedinfections AT wangm silvercoatedgoldnanorodsasapromisingantimicrobialagentinthetreatmentofcancerrelatedinfections AT webstertj silvercoatedgoldnanorodsasapromisingantimicrobialagentinthetreatmentofcancerrelatedinfections
_version_	1718402905862569984

Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections

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