Serum Biomarkers in Carotid Artery Disease

Carotid artery disease is considered a major cause of strokes and there is a need for early disease detection and management. Although imaging techniques have been developed for the diagnosis of carotid artery disease and different imaging-based markers have been proposed for the characterization of...

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Autores principales:	Vassiliki I. Kigka, Vassiliki Potsika, Michalis Mantzaris, Vassilis Tsakanikas, Igor Koncar, Dimitrios I. Fotiadis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carotid artery disease carotid stenosis atherosclerosis serum biomarkers risk stratification ultrasound Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8e9d074d2c6448a581663090893ea6cc
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spelling	oai:doaj.org-article:8e9d074d2c6448a581663090893ea6cc2021-11-25T17:21:59ZSerum Biomarkers in Carotid Artery Disease10.3390/diagnostics111121432075-4418https://doaj.org/article/8e9d074d2c6448a581663090893ea6cc2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2143https://doaj.org/toc/2075-4418Carotid artery disease is considered a major cause of strokes and there is a need for early disease detection and management. Although imaging techniques have been developed for the diagnosis of carotid artery disease and different imaging-based markers have been proposed for the characterization of atherosclerotic plaques, there is still need for a definition of high-risk plaques in asymptomatic patients who may benefit from surgical intervention. Measurement of circulating biomarkers is a promising method to assist in patient-specific disease management, but the lack of robust clinical evidence limits their use as a standard of care. The purpose of this review paper is to present circulating biomarkers related to carotid artery diagnosis and prognosis, which are mainly provided by statistical-based clinical studies. The result of our investigation showed that typical well-established inflammatory biomarkers and biomarkers related to patient lipid profiles are associated with carotid artery disease. In addition to this, more specialized types of biomarkers, such as endothelial and cell adhesion, matrix degrading, and metabolic biomarkers seem to be associated with different carotid artery disease outputs, assisting vascular specialists in selecting patients at high risk for stroke and in need of intervention.Vassiliki I. KigkaVassiliki PotsikaMichalis MantzarisVassilis TsakanikasIgor KoncarDimitrios I. FotiadisMDPI AGarticlecarotid artery diseasecarotid stenosisatherosclerosisserum biomarkersrisk stratificationultrasoundMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2143, p 2143 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carotid artery disease carotid stenosis atherosclerosis serum biomarkers risk stratification ultrasound Medicine (General) R5-920
spellingShingle	carotid artery disease carotid stenosis atherosclerosis serum biomarkers risk stratification ultrasound Medicine (General) R5-920 Vassiliki I. Kigka Vassiliki Potsika Michalis Mantzaris Vassilis Tsakanikas Igor Koncar Dimitrios I. Fotiadis Serum Biomarkers in Carotid Artery Disease
description	Carotid artery disease is considered a major cause of strokes and there is a need for early disease detection and management. Although imaging techniques have been developed for the diagnosis of carotid artery disease and different imaging-based markers have been proposed for the characterization of atherosclerotic plaques, there is still need for a definition of high-risk plaques in asymptomatic patients who may benefit from surgical intervention. Measurement of circulating biomarkers is a promising method to assist in patient-specific disease management, but the lack of robust clinical evidence limits their use as a standard of care. The purpose of this review paper is to present circulating biomarkers related to carotid artery diagnosis and prognosis, which are mainly provided by statistical-based clinical studies. The result of our investigation showed that typical well-established inflammatory biomarkers and biomarkers related to patient lipid profiles are associated with carotid artery disease. In addition to this, more specialized types of biomarkers, such as endothelial and cell adhesion, matrix degrading, and metabolic biomarkers seem to be associated with different carotid artery disease outputs, assisting vascular specialists in selecting patients at high risk for stroke and in need of intervention.
format	article
author	Vassiliki I. Kigka Vassiliki Potsika Michalis Mantzaris Vassilis Tsakanikas Igor Koncar Dimitrios I. Fotiadis
author_facet	Vassiliki I. Kigka Vassiliki Potsika Michalis Mantzaris Vassilis Tsakanikas Igor Koncar Dimitrios I. Fotiadis
author_sort	Vassiliki I. Kigka
title	Serum Biomarkers in Carotid Artery Disease
title_short	Serum Biomarkers in Carotid Artery Disease
title_full	Serum Biomarkers in Carotid Artery Disease
title_fullStr	Serum Biomarkers in Carotid Artery Disease
title_full_unstemmed	Serum Biomarkers in Carotid Artery Disease
title_sort	serum biomarkers in carotid artery disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8e9d074d2c6448a581663090893ea6cc
work_keys_str_mv	AT vassilikiikigka serumbiomarkersincarotidarterydisease AT vassilikipotsika serumbiomarkersincarotidarterydisease AT michalismantzaris serumbiomarkersincarotidarterydisease AT vassilistsakanikas serumbiomarkersincarotidarterydisease AT igorkoncar serumbiomarkersincarotidarterydisease AT dimitriosifotiadis serumbiomarkersincarotidarterydisease
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Serum Biomarkers in Carotid Artery Disease

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