Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1

Makiko Endo,1 Kaori Odaira,2 Ryohei Ono,3 Go Kurauchi,4 Atsushi Koseki,5 Momoko Goto,3 Yumi Sato,4 Seiko Kon,6 Norio Watanabe,7 Norio Sugawara,8 Hiroto Takada,6 En Kimura9 1Clinical Research Unit, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan;...

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Autores principales:	Endo M, Odaira K, Ono R, Kurauchi G, Koseki A, Goto M, Sato Y, Kon S, Watanabe N, Sugawara N, Takada H, Kimura E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	depression excessive daytime sleepiness chronic illness psychosocial perspective Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8e9d444e6be04f928282c7bba0265ecf
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spelling	oai:doaj.org-article:8e9d444e6be04f928282c7bba0265ecf2021-12-02T03:34:13ZHealth-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 11178-2021https://doaj.org/article/8e9d444e6be04f928282c7bba0265ecf2019-01-01T00:00:00Zhttps://www.dovepress.com/health-related-quality-of-life-and-its-correlates-in-japanese-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Makiko Endo,1 Kaori Odaira,2 Ryohei Ono,3 Go Kurauchi,4 Atsushi Koseki,5 Momoko Goto,3 Yumi Sato,4 Seiko Kon,6 Norio Watanabe,7 Norio Sugawara,8 Hiroto Takada,6 En Kimura9 1Clinical Research Unit, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan; 2Regional Medical Liaison Office, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 3Section for Development and Disability Training, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 4Department of Rehabilitation, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 5Section for Development and Disability Training, National Hospital Organization, Hanamaki Hospital, Hanamaki, Iwate 025-0033, Japan; 6Department of Neurology, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 7School of Public Health, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; 8Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan; 9Department of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan Purpose: Myotonic dystrophy type 1 (DM1) is a common form of muscular dystrophy that presents with a variety of symptoms that can affect patients’ quality of life (QoL). Despite the importance of clarifying patients’ subjective experience in both physical and psychosocial aspects for improved symptom management, there is lack of evidence concerning QoL of patients with DM1 in Japan.Patients and methods: A cross-sectional study was performed with 51 DM1 patients who completed questionnaires that measured health-related QoL (HRQoL), depression, and daytime sleepiness. Activities of daily living, body mass index (BMI), and genetic information were also collected, together with general demographic information. Correlation analyses using these variables were performed. Furthermore, regression analysis was utilized to assess the relationship that HRQoL, depression, and daytime sleepiness scores have with other variables.Results: Physical component summary (PCS) score was affected by the disease more than the mental component summary (MCS) score among study participants. Moderate correlation was observed between PCS and depression, PCS and Barthel index, and depression and daytime sleepiness. Regression analysis revealed that age, sex, cytosine–thymine–guanine repeats, and BMI did not predict the aforementioned dependent variables.Conclusion: DM1 symptoms influenced physical component scores more than mental component scores, although the state of physical wellness seemed to affect patients’ mood. Explaining the QoL of these patients only using biologic and genetic characteristics was not sufficient. We conclude that social and psychological aspects of these patients’ lives and the nature of adjustments made by patients due to DM1 to require further examination in order to improve the standard of care. Keywords: depression, excessive daytime sleepiness, chronic illness, psychosocial perspective Endo MOdaira KOno RKurauchi GKoseki AGoto MSato YKon SWatanabe NSugawara NTakada HKimura EDove Medical Pressarticledepressionexcessive daytime sleepinesschronic illnesspsychosocial perspectiveNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 219-226 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression excessive daytime sleepiness chronic illness psychosocial perspective Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression excessive daytime sleepiness chronic illness psychosocial perspective Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Endo M Odaira K Ono R Kurauchi G Koseki A Goto M Sato Y Kon S Watanabe N Sugawara N Takada H Kimura E Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1
description	Makiko Endo,1 Kaori Odaira,2 Ryohei Ono,3 Go Kurauchi,4 Atsushi Koseki,5 Momoko Goto,3 Yumi Sato,4 Seiko Kon,6 Norio Watanabe,7 Norio Sugawara,8 Hiroto Takada,6 En Kimura9 1Clinical Research Unit, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan; 2Regional Medical Liaison Office, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 3Section for Development and Disability Training, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 4Department of Rehabilitation, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 5Section for Development and Disability Training, National Hospital Organization, Hanamaki Hospital, Hanamaki, Iwate 025-0033, Japan; 6Department of Neurology, National Hospital Organization, Aomori Hospital, Namioka, Aomori 038-1331, Japan; 7School of Public Health, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; 8Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan; 9Department of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan Purpose: Myotonic dystrophy type 1 (DM1) is a common form of muscular dystrophy that presents with a variety of symptoms that can affect patients’ quality of life (QoL). Despite the importance of clarifying patients’ subjective experience in both physical and psychosocial aspects for improved symptom management, there is lack of evidence concerning QoL of patients with DM1 in Japan.Patients and methods: A cross-sectional study was performed with 51 DM1 patients who completed questionnaires that measured health-related QoL (HRQoL), depression, and daytime sleepiness. Activities of daily living, body mass index (BMI), and genetic information were also collected, together with general demographic information. Correlation analyses using these variables were performed. Furthermore, regression analysis was utilized to assess the relationship that HRQoL, depression, and daytime sleepiness scores have with other variables.Results: Physical component summary (PCS) score was affected by the disease more than the mental component summary (MCS) score among study participants. Moderate correlation was observed between PCS and depression, PCS and Barthel index, and depression and daytime sleepiness. Regression analysis revealed that age, sex, cytosine–thymine–guanine repeats, and BMI did not predict the aforementioned dependent variables.Conclusion: DM1 symptoms influenced physical component scores more than mental component scores, although the state of physical wellness seemed to affect patients’ mood. Explaining the QoL of these patients only using biologic and genetic characteristics was not sufficient. We conclude that social and psychological aspects of these patients’ lives and the nature of adjustments made by patients due to DM1 to require further examination in order to improve the standard of care. Keywords: depression, excessive daytime sleepiness, chronic illness, psychosocial perspective
format	article
author	Endo M Odaira K Ono R Kurauchi G Koseki A Goto M Sato Y Kon S Watanabe N Sugawara N Takada H Kimura E
author_facet	Endo M Odaira K Ono R Kurauchi G Koseki A Goto M Sato Y Kon S Watanabe N Sugawara N Takada H Kimura E
author_sort	Endo M
title	Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1
title_short	Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1
title_full	Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1
title_fullStr	Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1
title_full_unstemmed	Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1
title_sort	health-related quality of life and its correlates in japanese patients with myotonic dystrophy type 1
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8e9d444e6be04f928282c7bba0265ecf
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Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1

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