In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.

<h4>Background</h4>Zebrafish (Danio rerio) has a remarkable capacity to regenerate many organs and tissues. During larval stages the fin fold allows the possibility of performing long time-lapse imaging making this system very appealing to study the relationships between tissue movements...

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Autores principales:	Rita Mateus, Telmo Pereira, Sara Sousa, Joana Esteves de Lima, Susana Pascoal, Leonor Saúde, Antonio Jacinto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8e9d7b763d084a5ea8f89458869047b0
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spelling	oai:doaj.org-article:8e9d7b763d084a5ea8f89458869047b02021-11-18T08:04:23ZIn vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.1932-620310.1371/journal.pone.0051766https://doaj.org/article/8e9d7b763d084a5ea8f89458869047b02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284763/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Zebrafish (Danio rerio) has a remarkable capacity to regenerate many organs and tissues. During larval stages the fin fold allows the possibility of performing long time-lapse imaging making this system very appealing to study the relationships between tissue movements, cell migration and proliferation necessary for the regeneration process.<h4>Results</h4>Through the combined use of transgenic fluorescently-labeled animals and confocal microscopy imaging, we characterized in vivo the complete fin fold regeneration process. We show, for the first time, that there is an increase in the global rate of epidermal growth as a response to tissue loss. Also enhanced significantly is cell proliferation, which upon amputation happens in a broad area concerning the amputation level and not in a blastema-restricted way. This reveals a striking difference with regard to the adult fin regeneration system. Finally, an accumulation of migratory, shape-changing fibroblasts occurs proximally to the wound area, resembling a blastemal-like structure, which may act as a signaling center for the regeneration process to proceed.<h4>Conclusions</h4>These findings provide a novel in vivo description of fundamental mechanisms occurring during the fin fold regeneration process, thereby contributing to a better knowledge of this regenerative system and to reveal variations in the epimorphic regeneration field.Rita MateusTelmo PereiraSara SousaJoana Esteves de LimaSusana PascoalLeonor SaúdeAntonio JacintoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51766 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rita Mateus Telmo Pereira Sara Sousa Joana Esteves de Lima Susana Pascoal Leonor Saúde Antonio Jacinto In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
description	<h4>Background</h4>Zebrafish (Danio rerio) has a remarkable capacity to regenerate many organs and tissues. During larval stages the fin fold allows the possibility of performing long time-lapse imaging making this system very appealing to study the relationships between tissue movements, cell migration and proliferation necessary for the regeneration process.<h4>Results</h4>Through the combined use of transgenic fluorescently-labeled animals and confocal microscopy imaging, we characterized in vivo the complete fin fold regeneration process. We show, for the first time, that there is an increase in the global rate of epidermal growth as a response to tissue loss. Also enhanced significantly is cell proliferation, which upon amputation happens in a broad area concerning the amputation level and not in a blastema-restricted way. This reveals a striking difference with regard to the adult fin regeneration system. Finally, an accumulation of migratory, shape-changing fibroblasts occurs proximally to the wound area, resembling a blastemal-like structure, which may act as a signaling center for the regeneration process to proceed.<h4>Conclusions</h4>These findings provide a novel in vivo description of fundamental mechanisms occurring during the fin fold regeneration process, thereby contributing to a better knowledge of this regenerative system and to reveal variations in the epimorphic regeneration field.
format	article
author	Rita Mateus Telmo Pereira Sara Sousa Joana Esteves de Lima Susana Pascoal Leonor Saúde Antonio Jacinto
author_facet	Rita Mateus Telmo Pereira Sara Sousa Joana Esteves de Lima Susana Pascoal Leonor Saúde Antonio Jacinto
author_sort	Rita Mateus
title	In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
title_short	In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
title_full	In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
title_fullStr	In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
title_full_unstemmed	In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
title_sort	in vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8e9d7b763d084a5ea8f89458869047b0
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_version_	1718422242673557504

In vivo cell and tissue dynamics underlying zebrafish fin fold regeneration.

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