Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ole A. Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A. Howard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8e9de18872a44db2b4a88a0afeac0789
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8e9de18872a44db2b4a88a0afeac0789
record_format	dspace
spelling	oai:doaj.org-article:8e9de18872a44db2b4a88a0afeac07892021-12-02T11:35:57ZProgrammable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity10.1038/s42003-021-01790-22399-3642https://doaj.org/article/8e9de18872a44db2b4a88a0afeac07892021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01790-2https://doaj.org/toc/2399-3642Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in vivo half-life extension, cellular cytotoxicity dependent on the cell surface levels of EGFR and can inhibit growth of BRAF mutated EGFR-positive tumours in mice.Ole A. MandrupSui Ching OngSimon LykkemarkAnders DinesenImke Rudnik-JansenNiels Frederik Dagnæs-HansenJan Terje AndersenLuis Alvarez-VallinaKenneth A. HowardNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ole A. Mandrup Sui Ching Ong Simon Lykkemark Anders Dinesen Imke Rudnik-Jansen Niels Frederik Dagnæs-Hansen Jan Terje Andersen Luis Alvarez-Vallina Kenneth A. Howard Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
description	Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in vivo half-life extension, cellular cytotoxicity dependent on the cell surface levels of EGFR and can inhibit growth of BRAF mutated EGFR-positive tumours in mice.
format	article
author	Ole A. Mandrup Sui Ching Ong Simon Lykkemark Anders Dinesen Imke Rudnik-Jansen Niels Frederik Dagnæs-Hansen Jan Terje Andersen Luis Alvarez-Vallina Kenneth A. Howard
author_facet	Ole A. Mandrup Sui Ching Ong Simon Lykkemark Anders Dinesen Imke Rudnik-Jansen Niels Frederik Dagnæs-Hansen Jan Terje Andersen Luis Alvarez-Vallina Kenneth A. Howard
author_sort	Ole A. Mandrup
title	Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
title_short	Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
title_full	Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
title_fullStr	Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
title_full_unstemmed	Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
title_sort	programmable half-life and anti-tumour effects of bispecific t-cell engager-albumin fusions with tuned fcrn affinity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8e9de18872a44db2b4a88a0afeac0789
work_keys_str_mv	AT oleamandrup programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT suichingong programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT simonlykkemark programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT andersdinesen programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT imkerudnikjansen programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT nielsfrederikdagnæshansen programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT janterjeandersen programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT luisalvarezvallina programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity AT kennethahoward programmablehalflifeandantitumoureffectsofbispecifictcellengageralbuminfusionswithtunedfcrnaffinity
_version_	1718395832141611008

Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Ejemplares similares