IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in hu...

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Autores principales: Alyse L. Frisbee, Mahmoud M. Saleh, Mary K. Young, Jhansi L. Leslie, Morgan E. Simpson, Mayuresh M. Abhyankar, Carrie A. Cowardin, Jennie Z. Ma, Patcharin Pramoonjago, Stephen D. Turner, Alice P. Liou, Erica L. Buonomo, William A. Petri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/8ea0571b5e634edeb6f07d5f54e6abfd
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Sumario:Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in human C. difficile patients.

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