IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in hu...

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Autores principales:	Alyse L. Frisbee, Mahmoud M. Saleh, Mary K. Young, Jhansi L. Leslie, Morgan E. Simpson, Mayuresh M. Abhyankar, Carrie A. Cowardin, Jennie Z. Ma, Patcharin Pramoonjago, Stephen D. Turner, Alice P. Liou, Erica L. Buonomo, William A. Petri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ea0571b5e634edeb6f07d5f54e6abfd
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spelling	oai:doaj.org-article:8ea0571b5e634edeb6f07d5f54e6abfd2021-12-02T16:57:23ZIL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection10.1038/s41467-019-10733-92041-1723https://doaj.org/article/8ea0571b5e634edeb6f07d5f54e6abfd2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10733-9https://doaj.org/toc/2041-1723Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in human C. difficile patients.Alyse L. FrisbeeMahmoud M. SalehMary K. YoungJhansi L. LeslieMorgan E. SimpsonMayuresh M. AbhyankarCarrie A. CowardinJennie Z. MaPatcharin PramoonjagoStephen D. TurnerAlice P. LiouErica L. BuonomoWilliam A. PetriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyse L. Frisbee Mahmoud M. Saleh Mary K. Young Jhansi L. Leslie Morgan E. Simpson Mayuresh M. Abhyankar Carrie A. Cowardin Jennie Z. Ma Patcharin Pramoonjago Stephen D. Turner Alice P. Liou Erica L. Buonomo William A. Petri IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
description	Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in human C. difficile patients.
format	article
author	Alyse L. Frisbee Mahmoud M. Saleh Mary K. Young Jhansi L. Leslie Morgan E. Simpson Mayuresh M. Abhyankar Carrie A. Cowardin Jennie Z. Ma Patcharin Pramoonjago Stephen D. Turner Alice P. Liou Erica L. Buonomo William A. Petri
author_facet	Alyse L. Frisbee Mahmoud M. Saleh Mary K. Young Jhansi L. Leslie Morgan E. Simpson Mayuresh M. Abhyankar Carrie A. Cowardin Jennie Z. Ma Patcharin Pramoonjago Stephen D. Turner Alice P. Liou Erica L. Buonomo William A. Petri
author_sort	Alyse L. Frisbee
title	IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
title_short	IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
title_full	IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
title_fullStr	IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
title_full_unstemmed	IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
title_sort	il-33 drives group 2 innate lymphoid cell-mediated protection during clostridium difficile infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8ea0571b5e634edeb6f07d5f54e6abfd
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IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

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