Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study

Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study

Abstract Few data are available regarding fracture risk in patients treated with glucocorticoids, including patients with kidney disease. A population-based retrospective cohort study was performed using Health Insurance Review and Assessment Service database, a South Korean nationwide cohort set. T...

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Autores principales: Eunyoung Lee, Min-Jeong Lee, Bumhee Park, Inwhee Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8ea1d58f90e843a8a791d38142bfbb30
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spelling oai:doaj.org-article:8ea1d58f90e843a8a791d38142bfbb302021-12-02T16:43:42ZRisk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study10.1038/s41598-020-70935-w2045-2322https://doaj.org/article/8ea1d58f90e843a8a791d38142bfbb302020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70935-whttps://doaj.org/toc/2045-2322Abstract Few data are available regarding fracture risk in patients treated with glucocorticoids, including patients with kidney disease. A population-based retrospective cohort study was performed using Health Insurance Review and Assessment Service database, a South Korean nationwide cohort set. This study identified 44,702 patients with diagnosis code of kidney diseases who received a renal biopsy between January 1, 2012 and December 31, 2017. A total of 8,624 patients met all study inclusion criteria. A total of 1,406 fractures of any site were observed in the study period. The glucocorticoid-exposed group had more fractures than the unexposed (14.4% vs 8.8%, P < 0.0001). Vertebral fractures were the most common, followed by upper limb, and lower limb fractures. The exposed group showed a remarkably higher hazard ratio of fracture risk (HR 6.0, 95% CI 5.01–7.23) than the unexposed group, indicating systemic glucocorticoid exposure was highly associated with fracture risk. Although HR increased at doses even less than 5 mg/day, it was independent of dose. Older age showed a significant effect on fracture risk (HR 1.2, 95% CI 1.05–1.44), even after adjusting for systemic glucocorticoid exposure. Glucocorticoids was associated with higher risk of fracture even at a low daily dose and short term exposure.Eunyoung LeeMin-Jeong LeeBumhee ParkInwhee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Eunyoung Lee
Min-Jeong Lee
Bumhee Park
Inwhee Park
Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
description Abstract Few data are available regarding fracture risk in patients treated with glucocorticoids, including patients with kidney disease. A population-based retrospective cohort study was performed using Health Insurance Review and Assessment Service database, a South Korean nationwide cohort set. This study identified 44,702 patients with diagnosis code of kidney diseases who received a renal biopsy between January 1, 2012 and December 31, 2017. A total of 8,624 patients met all study inclusion criteria. A total of 1,406 fractures of any site were observed in the study period. The glucocorticoid-exposed group had more fractures than the unexposed (14.4% vs 8.8%, P < 0.0001). Vertebral fractures were the most common, followed by upper limb, and lower limb fractures. The exposed group showed a remarkably higher hazard ratio of fracture risk (HR 6.0, 95% CI 5.01–7.23) than the unexposed group, indicating systemic glucocorticoid exposure was highly associated with fracture risk. Although HR increased at doses even less than 5 mg/day, it was independent of dose. Older age showed a significant effect on fracture risk (HR 1.2, 95% CI 1.05–1.44), even after adjusting for systemic glucocorticoid exposure. Glucocorticoids was associated with higher risk of fracture even at a low daily dose and short term exposure.
format article
author Eunyoung Lee
Min-Jeong Lee
Bumhee Park
Inwhee Park
author_facet Eunyoung Lee
Min-Jeong Lee
Bumhee Park
Inwhee Park
author_sort Eunyoung Lee
title Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
title_short Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
title_full Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
title_fullStr Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
title_full_unstemmed Risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
title_sort risk of fracture according to glucocorticoid use after renal biopsy: a nationwide population-based study
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/8ea1d58f90e843a8a791d38142bfbb30
work_keys_str_mv AT eunyounglee riskoffractureaccordingtoglucocorticoiduseafterrenalbiopsyanationwidepopulationbasedstudy
AT minjeonglee riskoffractureaccordingtoglucocorticoiduseafterrenalbiopsyanationwidepopulationbasedstudy
AT bumheepark riskoffractureaccordingtoglucocorticoiduseafterrenalbiopsyanationwidepopulationbasedstudy
AT inwheepark riskoffractureaccordingtoglucocorticoiduseafterrenalbiopsyanationwidepopulationbasedstudy
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