Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery

Yelda B &Ouml;zkurt, Arzu Taskiran, Nadire Erdogan, Baran Kandemir, &Ouml;mer K Dog?anDepartment of Ophthalmology, Kartal Training and Research Hospital, Istanbul, TurkeyPurpose: To evaluate the influence of irrigation of the anterior chamber with heparin sodium on postoperative infl...

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Autores principales:	Yelda B &Ouml;zkurt, Arzu Taskiran, Nadire Erdogan, Baran Kandemir, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8ea2217dedb64fc3a6edbd4913580d90
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spelling	oai:doaj.org-article:8ea2217dedb64fc3a6edbd4913580d902021-12-02T05:54:18ZEffect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery1177-54671177-5483https://doaj.org/article/8ea2217dedb64fc3a6edbd4913580d902009-06-01T00:00:00Zhttp://www.dovepress.com/effect-of-heparin-in-the-intraocular-irrigating-solution-on-postoperat-a3262https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yelda B &Ouml;zkurt, Arzu Taskiran, Nadire Erdogan, Baran Kandemir, &Ouml;mer K Dog?anDepartment of Ophthalmology, Kartal Training and Research Hospital, Istanbul, TurkeyPurpose: To evaluate the influence of irrigation of the anterior chamber with heparin sodium on postoperative inflammation after pediatric cataract surgery. Setting: Kartal Training and Research Hospital, First Eye Clinic, Istanbul, Turkey.Design: Randomized prospective double-blind study.Methods: Fourteen consecutive eyes from 14 patients aged 8.9 &plusmn; 5.9 years, (range 3&ndash;18 years) (group 1) and 19 eyes from 19 patients aged 9.1 &plusmn; 5.2 (range 1.5&ndash;18 years) (group 2) underwent pediatric cataract surgery. Five patients in group 1 were between three and five years old. One patient was 1.5 years old and six patients in group 2 were between three and five years old. During the procedure, group 1 received anterior chamber irrigation with heparin sodium (5 IU/cc) and 1 ml of heparin sodium (concentration 10 IU/ml) added to the irrigating balanced salt solution (BSS Plus; Alcon Laboratories, Inc., Fort Worth, TX, USA) while group 2 received BSS without heparin sodium only. Cases aged under three years received anterior vitrectomy in addition to posterior capsulorrhexis. One eye received anterior vitrectomy in group 1 and two eyes received anterior vitrectomy in group 2. Cases with preoperative complications were not included in the study. Early and late postoperative inflammatory complications, including fibrin formation, anterior and posterior synechia, cyclitic and pupillary membrane formation were recorded and compared.Results: Mild anterior chamber reaction was observed in three patients in Group 1, while nine cases in group 2 experienced marked anterior chamber reaction. In four of nine patients from group 2, anterior chamber reaction was severe and resulted in pupillary membrane and synechia despite treatment in the postoperative 7th day, while in all three cases in group 1, reaction disappeared by the 7th day.Conclusion: Anterior chamber irrigation with heparin during pediatric cataract surgery may minimize early inflammatory reaction and decrease the number of postoperative inflammatory related complications.Keywords: pediatric, cataract, surgery, inflammation Yelda B &Ouml;zkurtArzu TaskiranNadire ErdoganBaran Kandemiret al.Dove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 363-365 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yelda B &Ouml;zkurt Arzu Taskiran Nadire Erdogan Baran Kandemir et al. Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
description	Yelda B &Ouml;zkurt, Arzu Taskiran, Nadire Erdogan, Baran Kandemir, &Ouml;mer K Dog?anDepartment of Ophthalmology, Kartal Training and Research Hospital, Istanbul, TurkeyPurpose: To evaluate the influence of irrigation of the anterior chamber with heparin sodium on postoperative inflammation after pediatric cataract surgery. Setting: Kartal Training and Research Hospital, First Eye Clinic, Istanbul, Turkey.Design: Randomized prospective double-blind study.Methods: Fourteen consecutive eyes from 14 patients aged 8.9 &plusmn; 5.9 years, (range 3&ndash;18 years) (group 1) and 19 eyes from 19 patients aged 9.1 &plusmn; 5.2 (range 1.5&ndash;18 years) (group 2) underwent pediatric cataract surgery. Five patients in group 1 were between three and five years old. One patient was 1.5 years old and six patients in group 2 were between three and five years old. During the procedure, group 1 received anterior chamber irrigation with heparin sodium (5 IU/cc) and 1 ml of heparin sodium (concentration 10 IU/ml) added to the irrigating balanced salt solution (BSS Plus; Alcon Laboratories, Inc., Fort Worth, TX, USA) while group 2 received BSS without heparin sodium only. Cases aged under three years received anterior vitrectomy in addition to posterior capsulorrhexis. One eye received anterior vitrectomy in group 1 and two eyes received anterior vitrectomy in group 2. Cases with preoperative complications were not included in the study. Early and late postoperative inflammatory complications, including fibrin formation, anterior and posterior synechia, cyclitic and pupillary membrane formation were recorded and compared.Results: Mild anterior chamber reaction was observed in three patients in Group 1, while nine cases in group 2 experienced marked anterior chamber reaction. In four of nine patients from group 2, anterior chamber reaction was severe and resulted in pupillary membrane and synechia despite treatment in the postoperative 7th day, while in all three cases in group 1, reaction disappeared by the 7th day.Conclusion: Anterior chamber irrigation with heparin during pediatric cataract surgery may minimize early inflammatory reaction and decrease the number of postoperative inflammatory related complications.Keywords: pediatric, cataract, surgery, inflammation
format	article
author	Yelda B &Ouml;zkurt Arzu Taskiran Nadire Erdogan Baran Kandemir et al.
author_facet	Yelda B &Ouml;zkurt Arzu Taskiran Nadire Erdogan Baran Kandemir et al.
author_sort	Yelda B &Ouml;zkurt
title	Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
title_short	Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
title_full	Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
title_fullStr	Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
title_full_unstemmed	Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
title_sort	effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/8ea2217dedb64fc3a6edbd4913580d90
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Effect of heparin in the intraocular irrigating solution on postoperative inflammation in the pediatric cataract surgery

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