Network features of the mammalian circadian clock.

The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations...

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Autores principales:	Julie E Baggs, Tom S Price, Luciano DiTacchio, Satchidananda Panda, Garret A Fitzgerald, John B Hogenesch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8ea60c859af24d80ba4012c42648648a
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spelling	oai:doaj.org-article:8ea60c859af24d80ba4012c42648648a2021-11-25T05:33:46ZNetwork features of the mammalian circadian clock.1544-91731545-788510.1371/journal.pbio.1000052https://doaj.org/article/8ea60c859af24d80ba4012c42648648a2009-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19278294/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations are maintained over a wide range of disruptions. We developed a novel strategy termed Gene Dosage Network Analysis (GDNA) in which small interfering RNA (siRNA)-induced dose-dependent changes in gene expression were used to build gene association networks consistent with known biochemical constraints. The use of multiple doses powered the analysis to uncover several novel network features of the circadian clock, including proportional responses and signal propagation through interacting genetic modules. We also observed several examples where a gene is up-regulated following knockdown of its paralog, suggesting the clock network utilizes active compensatory mechanisms rather than simple redundancy to confer robustness and maintain function. We propose that these network features act in concert as a genetic buffering system to maintain clock function in the face of genetic and environmental perturbation.Julie E BaggsTom S PriceLuciano DiTacchioSatchidananda PandaGarret A FitzgeraldJohn B HogeneschPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 3, p e52 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Julie E Baggs Tom S Price Luciano DiTacchio Satchidananda Panda Garret A Fitzgerald John B Hogenesch Network features of the mammalian circadian clock.
description	The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations are maintained over a wide range of disruptions. We developed a novel strategy termed Gene Dosage Network Analysis (GDNA) in which small interfering RNA (siRNA)-induced dose-dependent changes in gene expression were used to build gene association networks consistent with known biochemical constraints. The use of multiple doses powered the analysis to uncover several novel network features of the circadian clock, including proportional responses and signal propagation through interacting genetic modules. We also observed several examples where a gene is up-regulated following knockdown of its paralog, suggesting the clock network utilizes active compensatory mechanisms rather than simple redundancy to confer robustness and maintain function. We propose that these network features act in concert as a genetic buffering system to maintain clock function in the face of genetic and environmental perturbation.
format	article
author	Julie E Baggs Tom S Price Luciano DiTacchio Satchidananda Panda Garret A Fitzgerald John B Hogenesch
author_facet	Julie E Baggs Tom S Price Luciano DiTacchio Satchidananda Panda Garret A Fitzgerald John B Hogenesch
author_sort	Julie E Baggs
title	Network features of the mammalian circadian clock.
title_short	Network features of the mammalian circadian clock.
title_full	Network features of the mammalian circadian clock.
title_fullStr	Network features of the mammalian circadian clock.
title_full_unstemmed	Network features of the mammalian circadian clock.
title_sort	network features of the mammalian circadian clock.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/8ea60c859af24d80ba4012c42648648a
work_keys_str_mv	AT julieebaggs networkfeaturesofthemammaliancircadianclock AT tomsprice networkfeaturesofthemammaliancircadianclock AT lucianoditacchio networkfeaturesofthemammaliancircadianclock AT satchidanandapanda networkfeaturesofthemammaliancircadianclock AT garretafitzgerald networkfeaturesofthemammaliancircadianclock AT johnbhogenesch networkfeaturesofthemammaliancircadianclock
_version_	1718414589818830848

Network features of the mammalian circadian clock.

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