Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A

Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A

Abstract Backbone N-methylation and macrocyclization improve the pharmacological properties of peptides by enhancing their proteolytic stability, membrane permeability and target selectivity. Borosins are backbone N-methylated peptide macrocycles derived from a precursor protein which contains a pep...

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Autores principales: Emmanuel Matabaro, Hannelore Kaspar, Paul Dahlin, Daniel L. V. Bader, Claudia E. Murar, Florian Staubli, Christopher M. Field, Jeffrey W. Bode, Markus Künzler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8ea7352d2f614b6baa94eeac5342cde2
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