Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

The clinical application of T cell bispecific antibodies (TCBs) is often limited by the lack of tumour-specific antigens. In this study, the authors present a strategy to increase TCB tumour-selectivity by adding an anti-CD3 moiety that can be specifically activated by tumor specific proteases in th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martina Geiger, Kay-Gunnar Stubenrauch, Johannes Sam, Wolfgang F. Richter, Gregor Jordan, Jan Eckmann, Carina Hage, Valeria Nicolini, Anne Freimoser-Grundschober, Mirko Ritter, Matthias E. Lauer, Henning Stahlberg, Philippe Ringler, Jigar Patel, Eric Sullivan, Sandra Grau-Richards, Stefan Endres, Sebastian Kobold, Pablo Umaña, Peter Brünker, Christian Klein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ea92b14dd394c6fac60d2c9ad4feca4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ea92b14dd394c6fac60d2c9ad4feca4
record_format	dspace
spelling	oai:doaj.org-article:8ea92b14dd394c6fac60d2c9ad4feca42021-12-02T17:45:00ZProtease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody10.1038/s41467-020-16838-w2041-1723https://doaj.org/article/8ea92b14dd394c6fac60d2c9ad4feca42020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16838-whttps://doaj.org/toc/2041-1723The clinical application of T cell bispecific antibodies (TCBs) is often limited by the lack of tumour-specific antigens. In this study, the authors present a strategy to increase TCB tumour-selectivity by adding an anti-CD3 moiety that can be specifically activated by tumor specific proteases in the tumor microenvironment.Martina GeigerKay-Gunnar StubenrauchJohannes SamWolfgang F. RichterGregor JordanJan EckmannCarina HageValeria NicoliniAnne Freimoser-GrundschoberMirko RitterMatthias E. LauerHenning StahlbergPhilippe RinglerJigar PatelEric SullivanSandra Grau-RichardsStefan EndresSebastian KoboldPablo UmañaPeter BrünkerChristian KleinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martina Geiger Kay-Gunnar Stubenrauch Johannes Sam Wolfgang F. Richter Gregor Jordan Jan Eckmann Carina Hage Valeria Nicolini Anne Freimoser-Grundschober Mirko Ritter Matthias E. Lauer Henning Stahlberg Philippe Ringler Jigar Patel Eric Sullivan Sandra Grau-Richards Stefan Endres Sebastian Kobold Pablo Umaña Peter Brünker Christian Klein Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
description	The clinical application of T cell bispecific antibodies (TCBs) is often limited by the lack of tumour-specific antigens. In this study, the authors present a strategy to increase TCB tumour-selectivity by adding an anti-CD3 moiety that can be specifically activated by tumor specific proteases in the tumor microenvironment.
format	article
author	Martina Geiger Kay-Gunnar Stubenrauch Johannes Sam Wolfgang F. Richter Gregor Jordan Jan Eckmann Carina Hage Valeria Nicolini Anne Freimoser-Grundschober Mirko Ritter Matthias E. Lauer Henning Stahlberg Philippe Ringler Jigar Patel Eric Sullivan Sandra Grau-Richards Stefan Endres Sebastian Kobold Pablo Umaña Peter Brünker Christian Klein
author_facet	Martina Geiger Kay-Gunnar Stubenrauch Johannes Sam Wolfgang F. Richter Gregor Jordan Jan Eckmann Carina Hage Valeria Nicolini Anne Freimoser-Grundschober Mirko Ritter Matthias E. Lauer Henning Stahlberg Philippe Ringler Jigar Patel Eric Sullivan Sandra Grau-Richards Stefan Endres Sebastian Kobold Pablo Umaña Peter Brünker Christian Klein
author_sort	Martina Geiger
title	Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
title_short	Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
title_full	Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
title_fullStr	Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
title_full_unstemmed	Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
title_sort	protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-t cell bispecific antibody
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8ea92b14dd394c6fac60d2c9ad4feca4
work_keys_str_mv	AT martinageiger proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT kaygunnarstubenrauch proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT johannessam proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT wolfgangfrichter proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT gregorjordan proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT janeckmann proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT carinahage proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT valerianicolini proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT annefreimosergrundschober proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT mirkoritter proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT matthiaselauer proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT henningstahlberg proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT philipperingler proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT jigarpatel proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT ericsullivan proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT sandragraurichards proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT stefanendres proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT sebastiankobold proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT pabloumana proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT peterbrunker proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody AT christianklein proteaseactivationusingantiidiotypicmasksenablestumorspecificityofafolatereceptor1tcellbispecificantibody
_version_	1718379600303620096

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

Ejemplares similares