Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies

Hangzhou Zhang,1 Yu Sun,1 Ang Tian,2 Xiang Xin Xue,2 Lin Wang,1 Ali Alquhali,1 Xizhuang Bai1 1Department of Sports Medicine and Joint Surgery, First Affiliated Hospital of China Medical University, 2School of Materials and Metallurgy, Northeastern University, Shenyang, People's Republic of C...

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Autores principales:	Zhang HZ, Sun Y, Tian A, Xue XX, Wang L, Alquhali A, Bai XZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8eb2bb8c6c1049fa8ac47285e715a37b
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spelling	oai:doaj.org-article:8eb2bb8c6c1049fa8ac47285e715a37b2021-12-02T04:57:28ZImproved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies1176-91141178-2013https://doaj.org/article/8eb2bb8c6c1049fa8ac47285e715a37b2013-11-01T00:00:00Zhttp://www.dovepress.com/improved-antibacterial-activity-and-biocompatibility-on-vancomycin-loa-a14935https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hangzhou Zhang,1 Yu Sun,1 Ang Tian,2 Xiang Xin Xue,2 Lin Wang,1 Ali Alquhali,1 Xizhuang Bai1 1Department of Sports Medicine and Joint Surgery, First Affiliated Hospital of China Medical University, 2School of Materials and Metallurgy, Northeastern University, Shenyang, People's Republic of China Abstract: The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO2 nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompatibility and potential utility as drug nanoreservoirs. The aim of the present study was to investigate the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo. Staphylococcus aureus was used to study the antibacterial properties of the NT-V. There were three study groups: the commercially pure titanium (Cp-Ti) group, the NT group (nonloaded vancomycin), and the NT-V group. We compared NT-V biocompatibility and antibacterial efficacy with those of the NT and Cp-Ti groups. Compared with Cp-Ti, NT-V showed good antibacterial effect both in vitro and in vivo. Although the NTs reduced the surface bacterial adhesion in vitro, implant infection still developed in in vivo studies. Furthermore, the results also revealed that both NTs and NT-V showed good biocompatibility. Therefore, the NTs loaded with antibiotic might be potentially used for future orthopedic implants. Keywords: TiO2 nanotubes, biocompatibility, antibacterial properties, osteoblasts, vancomycinZhang HZSun YTian AXue XXWang LAlquhali ABai XZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4379-4389 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang HZ Sun Y Tian A Xue XX Wang L Alquhali A Bai XZ Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
description	Hangzhou Zhang,1 Yu Sun,1 Ang Tian,2 Xiang Xin Xue,2 Lin Wang,1 Ali Alquhali,1 Xizhuang Bai1 1Department of Sports Medicine and Joint Surgery, First Affiliated Hospital of China Medical University, 2School of Materials and Metallurgy, Northeastern University, Shenyang, People's Republic of China Abstract: The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO2 nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompatibility and potential utility as drug nanoreservoirs. The aim of the present study was to investigate the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo. Staphylococcus aureus was used to study the antibacterial properties of the NT-V. There were three study groups: the commercially pure titanium (Cp-Ti) group, the NT group (nonloaded vancomycin), and the NT-V group. We compared NT-V biocompatibility and antibacterial efficacy with those of the NT and Cp-Ti groups. Compared with Cp-Ti, NT-V showed good antibacterial effect both in vitro and in vivo. Although the NTs reduced the surface bacterial adhesion in vitro, implant infection still developed in in vivo studies. Furthermore, the results also revealed that both NTs and NT-V showed good biocompatibility. Therefore, the NTs loaded with antibiotic might be potentially used for future orthopedic implants. Keywords: TiO2 nanotubes, biocompatibility, antibacterial properties, osteoblasts, vancomycin
format	article
author	Zhang HZ Sun Y Tian A Xue XX Wang L Alquhali A Bai XZ
author_facet	Zhang HZ Sun Y Tian A Xue XX Wang L Alquhali A Bai XZ
author_sort	Zhang HZ
title	Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
title_short	Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
title_full	Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
title_fullStr	Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
title_full_unstemmed	Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
title_sort	improved antibacterial activity and biocompatibility on vancomycin-loaded tio2 nanotubes: in vivo and in vitro studies
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/8eb2bb8c6c1049fa8ac47285e715a37b
work_keys_str_mv	AT zhanghz improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies AT suny improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies AT tiana improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies AT xuexx improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies AT wangl improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies AT alquhalia improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies AT baixz improvedantibacterialactivityandbiocompatibilityonvancomycinloadedtio2nanotubesinvivoandinvitrostudies
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Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies

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