Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats

Obesity has increased in epidemic proportions globally and the current antiobesity drugs have treatment limitations which further reduce treatment benefits. The aim of this study was to evaluate the effect of Allium sativum and Orlistat on insulin resistance, fatty acid content and metabolic hormone...

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Autores principales:	Ogunyemi Bukola Caroline, Osaretin A.T. Ebuehi, Oshanupin Adeola Cecilia, Ogunyemi Adewale Kayode
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Obesity Leptin Insulin Ghrelin A. sativum Orlistat Science Q
Acceso en línea:	https://doaj.org/article/8eb50ba032944a399b60ea8c9ead0cb1
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spelling	oai:doaj.org-article:8eb50ba032944a399b60ea8c9ead0cb12021-11-14T04:34:47ZEffect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats2468-227610.1016/j.sciaf.2021.e00994https://doaj.org/article/8eb50ba032944a399b60ea8c9ead0cb12021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2468227621002982https://doaj.org/toc/2468-2276Obesity has increased in epidemic proportions globally and the current antiobesity drugs have treatment limitations which further reduce treatment benefits. The aim of this study was to evaluate the effect of Allium sativum and Orlistat on insulin resistance, fatty acid content and metabolic hormones; leptin, ghrelin and adiponectin in high-fat diet-induced obese rat model. The sprague-dawley rats used in this study were fed with standard chow as control diet, Fat emulsion as high-fat diet (HFD), HFD+ Orlistat, HFD+ A. sativum extract and HFD+ Orlistat+ A. sativum extract. Free fatty acid, serum glucose, insulin, leptin, ghrelin, adiponectin, and Homeostasis model assessment for insulin resistance (HOMA-IR) index were determined using standard methods. HFD significantly increased (P < .001) body weight, serum glucose, free fatty acid content, serum insulin, HOMA-IR and serum leptin. Furthermore, HFD reduced the serum levels of ghrelin and adiponectin when compared to control rats. The combined administration of A. sativum and orlistat resulted in a decrease in the body weight and HOMA-IR and also improved serum levels of glucose, insulin, leptin, ghrelin and adiponectin in obese rats fed with HFD. This suggests A. sativum in combination with orlistat, has the potential to ameliorate insulin resistance and metabolic hormones disrupted by obesityOgunyemi Bukola CarolineOsaretin A.T. EbuehiOshanupin Adeola CeciliaOgunyemi Adewale KayodeElsevierarticleObesityLeptinInsulinGhrelinA. sativumOrlistatScienceQENScientific African, Vol 14, Iss , Pp e00994- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity Leptin Insulin Ghrelin A. sativum Orlistat Science Q
spellingShingle	Obesity Leptin Insulin Ghrelin A. sativum Orlistat Science Q Ogunyemi Bukola Caroline Osaretin A.T. Ebuehi Oshanupin Adeola Cecilia Ogunyemi Adewale Kayode Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
description	Obesity has increased in epidemic proportions globally and the current antiobesity drugs have treatment limitations which further reduce treatment benefits. The aim of this study was to evaluate the effect of Allium sativum and Orlistat on insulin resistance, fatty acid content and metabolic hormones; leptin, ghrelin and adiponectin in high-fat diet-induced obese rat model. The sprague-dawley rats used in this study were fed with standard chow as control diet, Fat emulsion as high-fat diet (HFD), HFD+ Orlistat, HFD+ A. sativum extract and HFD+ Orlistat+ A. sativum extract. Free fatty acid, serum glucose, insulin, leptin, ghrelin, adiponectin, and Homeostasis model assessment for insulin resistance (HOMA-IR) index were determined using standard methods. HFD significantly increased (P < .001) body weight, serum glucose, free fatty acid content, serum insulin, HOMA-IR and serum leptin. Furthermore, HFD reduced the serum levels of ghrelin and adiponectin when compared to control rats. The combined administration of A. sativum and orlistat resulted in a decrease in the body weight and HOMA-IR and also improved serum levels of glucose, insulin, leptin, ghrelin and adiponectin in obese rats fed with HFD. This suggests A. sativum in combination with orlistat, has the potential to ameliorate insulin resistance and metabolic hormones disrupted by obesity
format	article
author	Ogunyemi Bukola Caroline Osaretin A.T. Ebuehi Oshanupin Adeola Cecilia Ogunyemi Adewale Kayode
author_facet	Ogunyemi Bukola Caroline Osaretin A.T. Ebuehi Oshanupin Adeola Cecilia Ogunyemi Adewale Kayode
author_sort	Ogunyemi Bukola Caroline
title	Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
title_short	Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
title_full	Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
title_fullStr	Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
title_full_unstemmed	Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
title_sort	effect of allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8eb50ba032944a399b60ea8c9ead0cb1
work_keys_str_mv	AT ogunyemibukolacaroline effectofalliumsativumextractincombinationwithorlistatoninsulinresistanceanddisruptedmetabolichormonesinhighfatdietinducedobeserats AT osaretinatebuehi effectofalliumsativumextractincombinationwithorlistatoninsulinresistanceanddisruptedmetabolichormonesinhighfatdietinducedobeserats AT oshanupinadeolacecilia effectofalliumsativumextractincombinationwithorlistatoninsulinresistanceanddisruptedmetabolichormonesinhighfatdietinducedobeserats AT ogunyemiadewalekayode effectofalliumsativumextractincombinationwithorlistatoninsulinresistanceanddisruptedmetabolichormonesinhighfatdietinducedobeserats
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Effect of Allium sativum extract in combination -with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats

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