TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.

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Autores principales:	John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8eb6f2f6a3d047b7b8052b86b27f7725
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spelling	oai:doaj.org-article:8eb6f2f6a3d047b7b8052b86b27f77252021-12-02T15:33:50ZTEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts10.1038/s41467-020-15000-w2041-1723https://doaj.org/article/8eb6f2f6a3d047b7b8052b86b27f77252020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15000-whttps://doaj.org/toc/2041-1723Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.John FieldenKatherine WisemanIgnacio TorrecillaShudong LiSamuel HumeShih-Chieh ChiangAnnamaria RuggianoAbhay Narayan SinghRaimundo FreireSylvana HassaniehEnric DomingoIolanda VendrellRoman FischerBenedikt M. KesslerTimothy S. MaughanSherif F. El-KhamisyKristijan RamadanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John Fielden Katherine Wiseman Ignacio Torrecilla Shudong Li Samuel Hume Shih-Chieh Chiang Annamaria Ruggiano Abhay Narayan Singh Raimundo Freire Sylvana Hassanieh Enric Domingo Iolanda Vendrell Roman Fischer Benedikt M. Kessler Timothy S. Maughan Sherif F. El-Khamisy Kristijan Ramadan TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
description	Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.
format	article
author	John Fielden Katherine Wiseman Ignacio Torrecilla Shudong Li Samuel Hume Shih-Chieh Chiang Annamaria Ruggiano Abhay Narayan Singh Raimundo Freire Sylvana Hassanieh Enric Domingo Iolanda Vendrell Roman Fischer Benedikt M. Kessler Timothy S. Maughan Sherif F. El-Khamisy Kristijan Ramadan
author_facet	John Fielden Katherine Wiseman Ignacio Torrecilla Shudong Li Samuel Hume Shih-Chieh Chiang Annamaria Ruggiano Abhay Narayan Singh Raimundo Freire Sylvana Hassanieh Enric Domingo Iolanda Vendrell Roman Fischer Benedikt M. Kessler Timothy S. Maughan Sherif F. El-Khamisy Kristijan Ramadan
author_sort	John Fielden
title	TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
title_short	TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
title_full	TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
title_fullStr	TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
title_full_unstemmed	TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
title_sort	tex264 coordinates p97- and sprtn-mediated resolution of topoisomerase 1-dna adducts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8eb6f2f6a3d047b7b8052b86b27f7725
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TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

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