Effects of prenatal exposure to temephos on behavior and social interaction

Ana Olívia Martins Laurentino,1 Fabiana Durante de Medeiros,1 Juliana de Oliveira,1,2 Naiana da Rosa,1,2 Tamires Mateus Gomes,1 Eduardo de Medeiros Peretti,1 Josiane Somariva Prophiro,1,2 Jucélia J Fortunato1,2 1Neurobiology Laboratory of Inflammatory and Metabolic Processes,...

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Autores principales:	Martins Laurentino AO, Durante de Medeiros F, de Oliveira J, da Rosa N, Mateus Gomes T, de Medeiros Peretti E, Somariva Prophiro J, Fortunato JJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Neurodevelopment organophosphate toxicity temephos. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8eb78599ee3e44a79dd0ef1254328870
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spelling	oai:doaj.org-article:8eb78599ee3e44a79dd0ef12543288702021-12-02T04:28:44ZEffects of prenatal exposure to temephos on behavior and social interaction1178-2021https://doaj.org/article/8eb78599ee3e44a79dd0ef12543288702019-03-01T00:00:00Zhttps://www.dovepress.com/effects-of-prenatal-exposure-to-temephos-on-behavior-and-social-intera-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ana Olívia Martins Laurentino,1 Fabiana Durante de Medeiros,1 Juliana de Oliveira,1,2 Naiana da Rosa,1,2 Tamires Mateus Gomes,1 Eduardo de Medeiros Peretti,1 Josiane Somariva Prophiro,1,2 Jucélia J Fortunato1,2 1Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil; 2Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil Abstract: The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against Aedes aegypti in Brazil’s public health programs.Purpose: To evaluate behavioral effects of prenatal exposition to temephos in Wistar rats.Methods: First, we divided pregnant females into groups: those who received temephos diluted in distilled water by gavage between gestational days 6–13 and those who received only distilled water in the same period and volume. Then, we divided pups according to sex and exposure, and we made the behavioral tests on postnatal day 30.Results: Prenatal exposure to temephos caused hyperactivity, stereotyped behavior, and social impairment in animals.Conclusion: These results are similar to the altered behavior presented in some neurobiological diseases models, like Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders, and this study may bring a red alert to the large use of temephos in Brazil, due to the damage caused by its exposure. Keywords: neurodevelopment, organophosphate, toxicity, temephos  Martins Laurentino AODurante de Medeiros Fde Oliveira Jda Rosa NMateus Gomes Tde Medeiros Peretti ESomariva Prophiro JFortunato JJDove Medical PressarticleNeurodevelopmentorganophosphatetoxicitytemephos.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 669-673 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurodevelopment organophosphate toxicity temephos. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurodevelopment organophosphate toxicity temephos. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Martins Laurentino AO Durante de Medeiros F de Oliveira J da Rosa N Mateus Gomes T de Medeiros Peretti E Somariva Prophiro J Fortunato JJ Effects of prenatal exposure to temephos on behavior and social interaction
description	Ana Olívia Martins Laurentino,1 Fabiana Durante de Medeiros,1 Juliana de Oliveira,1,2 Naiana da Rosa,1,2 Tamires Mateus Gomes,1 Eduardo de Medeiros Peretti,1 Josiane Somariva Prophiro,1,2 Jucélia J Fortunato1,2 1Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil; 2Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil Abstract: The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against Aedes aegypti in Brazil’s public health programs.Purpose: To evaluate behavioral effects of prenatal exposition to temephos in Wistar rats.Methods: First, we divided pregnant females into groups: those who received temephos diluted in distilled water by gavage between gestational days 6–13 and those who received only distilled water in the same period and volume. Then, we divided pups according to sex and exposure, and we made the behavioral tests on postnatal day 30.Results: Prenatal exposure to temephos caused hyperactivity, stereotyped behavior, and social impairment in animals.Conclusion: These results are similar to the altered behavior presented in some neurobiological diseases models, like Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders, and this study may bring a red alert to the large use of temephos in Brazil, due to the damage caused by its exposure. Keywords: neurodevelopment, organophosphate, toxicity, temephos
format	article
author	Martins Laurentino AO Durante de Medeiros F de Oliveira J da Rosa N Mateus Gomes T de Medeiros Peretti E Somariva Prophiro J Fortunato JJ
author_facet	Martins Laurentino AO Durante de Medeiros F de Oliveira J da Rosa N Mateus Gomes T de Medeiros Peretti E Somariva Prophiro J Fortunato JJ
author_sort	Martins Laurentino AO
title	Effects of prenatal exposure to temephos on behavior and social interaction
title_short	Effects of prenatal exposure to temephos on behavior and social interaction
title_full	Effects of prenatal exposure to temephos on behavior and social interaction
title_fullStr	Effects of prenatal exposure to temephos on behavior and social interaction
title_full_unstemmed	Effects of prenatal exposure to temephos on behavior and social interaction
title_sort	effects of prenatal exposure to temephos on behavior and social interaction
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8eb78599ee3e44a79dd0ef1254328870
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_version_	1718401201209344000

Effects of prenatal exposure to temephos on behavior and social interaction

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