Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth

The respiratory system is transformed in terms of functional change at birth to adapt to breathing air. Here, the authors examine the molecular changes behind the first breath in the mouse by Drop-seq based RNA sequencing, identifying activation of the unfolded protein response as a perinatal adapta...

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Autores principales:	Minzhe Guo, Yina Du, Jason J. Gokey, Samriddha Ray, Sheila M. Bell, Mike Adam, Parvathi Sudha, Anne Karina Perl, Hitesh Deshmukh, S. Steven Potter, Jeffrey A. Whitsett, Yan Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8eb91ce772554004b1c6305113841794
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spelling	oai:doaj.org-article:8eb91ce772554004b1c63051138417942021-12-02T14:35:37ZSingle cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth10.1038/s41467-018-07770-12041-1723https://doaj.org/article/8eb91ce772554004b1c63051138417942019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07770-1https://doaj.org/toc/2041-1723The respiratory system is transformed in terms of functional change at birth to adapt to breathing air. Here, the authors examine the molecular changes behind the first breath in the mouse by Drop-seq based RNA sequencing, identifying activation of the unfolded protein response as a perinatal adaptation of the lung.Minzhe GuoYina DuJason J. GokeySamriddha RaySheila M. BellMike AdamParvathi SudhaAnne Karina PerlHitesh DeshmukhS. Steven PotterJeffrey A. WhitsettYan XuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minzhe Guo Yina Du Jason J. Gokey Samriddha Ray Sheila M. Bell Mike Adam Parvathi Sudha Anne Karina Perl Hitesh Deshmukh S. Steven Potter Jeffrey A. Whitsett Yan Xu Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
description	The respiratory system is transformed in terms of functional change at birth to adapt to breathing air. Here, the authors examine the molecular changes behind the first breath in the mouse by Drop-seq based RNA sequencing, identifying activation of the unfolded protein response as a perinatal adaptation of the lung.
format	article
author	Minzhe Guo Yina Du Jason J. Gokey Samriddha Ray Sheila M. Bell Mike Adam Parvathi Sudha Anne Karina Perl Hitesh Deshmukh S. Steven Potter Jeffrey A. Whitsett Yan Xu
author_facet	Minzhe Guo Yina Du Jason J. Gokey Samriddha Ray Sheila M. Bell Mike Adam Parvathi Sudha Anne Karina Perl Hitesh Deshmukh S. Steven Potter Jeffrey A. Whitsett Yan Xu
author_sort	Minzhe Guo
title	Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
title_short	Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
title_full	Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
title_fullStr	Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
title_full_unstemmed	Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
title_sort	single cell rna analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8eb91ce772554004b1c6305113841794
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Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth

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