Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/8ebabe15d49943d1834201842048ea26 |
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oai:doaj.org-article:8ebabe15d49943d1834201842048ea262021-12-02T14:41:16ZBreast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance10.1038/s41467-018-03600-62041-1723https://doaj.org/article/8ebabe15d49943d1834201842048ea262018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03600-6https://doaj.org/toc/2041-1723Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells.Melissa A. MeyerJohn M. BaerBrett L. KnolhoffTimothy M. NyweningRoheena Z. PanniXinming SuKatherine N. WeilbaecherWilliam G. HawkinsCynthia MaRyan C. FieldsDavid C. LinehanGrant A. ChallenRoberta FaccioRebecca L. AftDavid G. DeNardoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Melissa A. Meyer John M. Baer Brett L. Knolhoff Timothy M. Nywening Roheena Z. Panni Xinming Su Katherine N. Weilbaecher William G. Hawkins Cynthia Ma Ryan C. Fields David C. Linehan Grant A. Challen Roberta Faccio Rebecca L. Aft David G. DeNardo Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| description |
Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells. |
| format |
article |
| author |
Melissa A. Meyer John M. Baer Brett L. Knolhoff Timothy M. Nywening Roheena Z. Panni Xinming Su Katherine N. Weilbaecher William G. Hawkins Cynthia Ma Ryan C. Fields David C. Linehan Grant A. Challen Roberta Faccio Rebecca L. Aft David G. DeNardo |
| author_facet |
Melissa A. Meyer John M. Baer Brett L. Knolhoff Timothy M. Nywening Roheena Z. Panni Xinming Su Katherine N. Weilbaecher William G. Hawkins Cynthia Ma Ryan C. Fields David C. Linehan Grant A. Challen Roberta Faccio Rebecca L. Aft David G. DeNardo |
| author_sort |
Melissa A. Meyer |
| title |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_short |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_full |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_fullStr |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_full_unstemmed |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_sort |
breast and pancreatic cancer interrupt irf8-dependent dendritic cell development to overcome immune surveillance |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/8ebabe15d49943d1834201842048ea26 |
| work_keys_str_mv |
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| _version_ |
1718389943922851840 |