Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China

Abstract We investigated cross-sectional associations between children’s neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Ment...

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Autores principales:	Sarah E. Rothenberg, Qiurong Chen, Jian Shen, Yanfen Nong, Hua Nong, Eva P. Trinh, Fred J. Biasini, Jihong Liu, Xiaoyun Zeng, Yunfeng Zou, Fengxiu Ouyang, Susan A. Korrick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ebda9c1a2804d5fa9c2624a233f51d5
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spelling	oai:doaj.org-article:8ebda9c1a2804d5fa9c2624a233f51d52021-12-02T13:26:37ZNeurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China10.1038/s41598-021-86761-72045-2322https://doaj.org/article/8ebda9c1a2804d5fa9c2624a233f51d52021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86761-7https://doaj.org/toc/2045-2322Abstract We investigated cross-sectional associations between children’s neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed using 16S rRNA gene profiling. Microbial diversity was characterized using alpha diversity patterns. Additionally, 3 coabundance factors were determined for the 25 most abundant taxa. Multivariable linear regression models were constructed to examine the relationships between Bayley scores (MDI and PDI) and children's gut microbiota. In adjusted models, MDI and PDI scores were not associated with alpha diversity indices. However, in adjusted models, MDI and PDI scores were positively associated with the first coabundance factor, which captured positive loadings for the genera Faecalibacterium, Sutterella, and Clostridium cluster XIVa. For an interquartile range increase in the first coabundance factor, MDI scores increased by 3.9 points [95% confidence interval (CI): 0, 7.7], while PDI scores increased by 8.6 points (95% CI 3.1, 14). Our results highlight the potential for gut microbial compositional characteristics to be important correlates of children's Bayley Scales performance at 36 months of age.Sarah E. RothenbergQiurong ChenJian ShenYanfen NongHua NongEva P. TrinhFred J. BiasiniJihong LiuXiaoyun ZengYunfeng ZouFengxiu OuyangSusan A. KorrickNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah E. Rothenberg Qiurong Chen Jian Shen Yanfen Nong Hua Nong Eva P. Trinh Fred J. Biasini Jihong Liu Xiaoyun Zeng Yunfeng Zou Fengxiu Ouyang Susan A. Korrick Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
description	Abstract We investigated cross-sectional associations between children’s neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed using 16S rRNA gene profiling. Microbial diversity was characterized using alpha diversity patterns. Additionally, 3 coabundance factors were determined for the 25 most abundant taxa. Multivariable linear regression models were constructed to examine the relationships between Bayley scores (MDI and PDI) and children's gut microbiota. In adjusted models, MDI and PDI scores were not associated with alpha diversity indices. However, in adjusted models, MDI and PDI scores were positively associated with the first coabundance factor, which captured positive loadings for the genera Faecalibacterium, Sutterella, and Clostridium cluster XIVa. For an interquartile range increase in the first coabundance factor, MDI scores increased by 3.9 points [95% confidence interval (CI): 0, 7.7], while PDI scores increased by 8.6 points (95% CI 3.1, 14). Our results highlight the potential for gut microbial compositional characteristics to be important correlates of children's Bayley Scales performance at 36 months of age.
format	article
author	Sarah E. Rothenberg Qiurong Chen Jian Shen Yanfen Nong Hua Nong Eva P. Trinh Fred J. Biasini Jihong Liu Xiaoyun Zeng Yunfeng Zou Fengxiu Ouyang Susan A. Korrick
author_facet	Sarah E. Rothenberg Qiurong Chen Jian Shen Yanfen Nong Hua Nong Eva P. Trinh Fred J. Biasini Jihong Liu Xiaoyun Zeng Yunfeng Zou Fengxiu Ouyang Susan A. Korrick
author_sort	Sarah E. Rothenberg
title	Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
title_short	Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
title_full	Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
title_fullStr	Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
title_full_unstemmed	Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
title_sort	neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ebda9c1a2804d5fa9c2624a233f51d5
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Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China

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