Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study

Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established...

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Autores principales:	Jacopo J.V. Branca, Donatello Carrino, Ferdinando Paternostro, Massimo Gulisano, Matteo Becatti, Lorenzo Di Cesare Mannelli, Alessandra Pacini
Formato:	article
Lenguaje:	EN
Publicado:	PAGEPress Publications 2021
Materias:	neuropathic pain oxaliplatin magnesium manganese zinc Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8ebe0643ec114442a735ae9c09c6d5b5
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spelling	oai:doaj.org-article:8ebe0643ec114442a735ae9c09c6d5b52021-11-11T07:39:52ZAntioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study10.4081/ejh.2021.32851121-760X2038-8306https://doaj.org/article/8ebe0643ec114442a735ae9c09c6d5b52021-11-01T00:00:00Zhttps://www.ejh.it/index.php/ejh/article/view/3285https://doaj.org/toc/1121-760Xhttps://doaj.org/toc/2038-8306 Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established that neurons are not the only cell type involved in chronic pain and that glial cells, mainly astrocytes and microglia, are involved in the initiation and maintenance of neuropathy. Among all the pathogenetic factors involved in neuropathic pain, an oxaliplatin-dependent oxidative stress plays a predominant role. In our study, the antioxidant properties of magnesium (Mg), manganese (Mn) and zinc (Zn) salts were evaluated in order to counteract microglial activation induced by oxaliplatin. The antioxidant efficacy of these metals was evaluated by the means of molecular and morphological assays on the BV-2 microglial cell line. Our data clearly show that Mg, Mn and Zn are able to prevent oxaliplatin-dependent microglial alterations by reducing both oxidative and endoplasmic reticulum stress. Jacopo J.V. BrancaDonatello CarrinoFerdinando PaternostroMassimo GulisanoMatteo BecattiLorenzo Di Cesare MannelliAlessandra PaciniPAGEPress Publicationsarticleneuropathic painoxaliplatinmagnesiummanganesezincBiology (General)QH301-705.5ENEuropean Journal of Histochemistry , Vol 65, Iss s1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuropathic pain oxaliplatin magnesium manganese zinc Biology (General) QH301-705.5
spellingShingle	neuropathic pain oxaliplatin magnesium manganese zinc Biology (General) QH301-705.5 Jacopo J.V. Branca Donatello Carrino Ferdinando Paternostro Massimo Gulisano Matteo Becatti Lorenzo Di Cesare Mannelli Alessandra Pacini Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
description	Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer treatment. However, it is also known to trigger neuropathy whose underlying neurobiological mechanisms are still under investigation and currently available treatments show limited efficacy. It is now established that neurons are not the only cell type involved in chronic pain and that glial cells, mainly astrocytes and microglia, are involved in the initiation and maintenance of neuropathy. Among all the pathogenetic factors involved in neuropathic pain, an oxaliplatin-dependent oxidative stress plays a predominant role. In our study, the antioxidant properties of magnesium (Mg), manganese (Mn) and zinc (Zn) salts were evaluated in order to counteract microglial activation induced by oxaliplatin. The antioxidant efficacy of these metals was evaluated by the means of molecular and morphological assays on the BV-2 microglial cell line. Our data clearly show that Mg, Mn and Zn are able to prevent oxaliplatin-dependent microglial alterations by reducing both oxidative and endoplasmic reticulum stress.
format	article
author	Jacopo J.V. Branca Donatello Carrino Ferdinando Paternostro Massimo Gulisano Matteo Becatti Lorenzo Di Cesare Mannelli Alessandra Pacini
author_facet	Jacopo J.V. Branca Donatello Carrino Ferdinando Paternostro Massimo Gulisano Matteo Becatti Lorenzo Di Cesare Mannelli Alessandra Pacini
author_sort	Jacopo J.V. Branca
title	Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
title_short	Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
title_full	Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
title_fullStr	Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
title_full_unstemmed	Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
title_sort	antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study
publisher	PAGEPress Publications
publishDate	2021
url	https://doaj.org/article/8ebe0643ec114442a735ae9c09c6d5b5
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Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study

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