The potential value of serum chemerin in patients with breast cancer

Abstract Breast cancer (BC) is one of the most dangerous malignant diseases in females. However, the reliable serum biomarkers of BC still need to be explored. Chemerin levels have been found to be associated with different types of cancer. This study aimed to evaluate the role of serum chemerin as...

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Autores principales:	Yanfang Song, Xianjin Zhu, Zhen Lin, Li Luo, Dan Wen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ec2a52c231549c8882c43eaa404777e
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spelling	oai:doaj.org-article:8ec2a52c231549c8882c43eaa404777e2021-12-02T14:02:54ZThe potential value of serum chemerin in patients with breast cancer10.1038/s41598-021-85986-w2045-2322https://doaj.org/article/8ec2a52c231549c8882c43eaa404777e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85986-whttps://doaj.org/toc/2045-2322Abstract Breast cancer (BC) is one of the most dangerous malignant diseases in females. However, the reliable serum biomarkers of BC still need to be explored. Chemerin levels have been found to be associated with different types of cancer. This study aimed to evaluate the role of serum chemerin as a biomarker of BC diagnosis, as well as the correlation between serum chemerin levels and clinicopathological features. The serum from 248 BC patients, 30 breast benign tumor patients, and 103 healthy controls were collected and serum chemerin levels were determined with enzyme-linked immunosorbent assay. We found that serum levels of chemerin in BC patients were higher than those in healthy control individuals (p < 0.05). The area under the ROC curve (AUC) for chemerin, CA15-3 and CEA was 0.703, 0.662 and 0.581, respectively, in distinguishing between breast cancer patients from healthy individuals, and the chemerin cutoff value was 100.327 ng/ml with a sensitivity of 56.60% and a specificity of 98.10%. The AUC for chemerin + CA15-3 was 0.822, which was higher than that for chemerin + CEA and CEA + CA15-3. Moreover, serum levels of chemerin were significantly associated with histologic grade, Ki67 expression, and menopausal status. However, no significant association was found between serum levels of chemerin and age, tumor size, metastase, ER status, PR status, and HER-2 status. Overall, our study suggested that the combination of chemerin with CA15-3 achieves relatively better diagnostic performance in the breast cancer. Elevated serum chemerin is associated with Ki67 expression levels and histologic grade.Yanfang SongXianjin ZhuZhen LinLi LuoDan WenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanfang Song Xianjin Zhu Zhen Lin Li Luo Dan Wen The potential value of serum chemerin in patients with breast cancer
description	Abstract Breast cancer (BC) is one of the most dangerous malignant diseases in females. However, the reliable serum biomarkers of BC still need to be explored. Chemerin levels have been found to be associated with different types of cancer. This study aimed to evaluate the role of serum chemerin as a biomarker of BC diagnosis, as well as the correlation between serum chemerin levels and clinicopathological features. The serum from 248 BC patients, 30 breast benign tumor patients, and 103 healthy controls were collected and serum chemerin levels were determined with enzyme-linked immunosorbent assay. We found that serum levels of chemerin in BC patients were higher than those in healthy control individuals (p < 0.05). The area under the ROC curve (AUC) for chemerin, CA15-3 and CEA was 0.703, 0.662 and 0.581, respectively, in distinguishing between breast cancer patients from healthy individuals, and the chemerin cutoff value was 100.327 ng/ml with a sensitivity of 56.60% and a specificity of 98.10%. The AUC for chemerin + CA15-3 was 0.822, which was higher than that for chemerin + CEA and CEA + CA15-3. Moreover, serum levels of chemerin were significantly associated with histologic grade, Ki67 expression, and menopausal status. However, no significant association was found between serum levels of chemerin and age, tumor size, metastase, ER status, PR status, and HER-2 status. Overall, our study suggested that the combination of chemerin with CA15-3 achieves relatively better diagnostic performance in the breast cancer. Elevated serum chemerin is associated with Ki67 expression levels and histologic grade.
format	article
author	Yanfang Song Xianjin Zhu Zhen Lin Li Luo Dan Wen
author_facet	Yanfang Song Xianjin Zhu Zhen Lin Li Luo Dan Wen
author_sort	Yanfang Song
title	The potential value of serum chemerin in patients with breast cancer
title_short	The potential value of serum chemerin in patients with breast cancer
title_full	The potential value of serum chemerin in patients with breast cancer
title_fullStr	The potential value of serum chemerin in patients with breast cancer
title_full_unstemmed	The potential value of serum chemerin in patients with breast cancer
title_sort	potential value of serum chemerin in patients with breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ec2a52c231549c8882c43eaa404777e
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The potential value of serum chemerin in patients with breast cancer

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