What are the links between hypoxia and Alzheimer’s disease?
Rahul Lall,1 Raihan Mohammed,1 Utkarsh Ojha21Department of Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine, Imperial College London, London, UKAbstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease. Histological characterization of amyloid pl...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8ec4a34afd1345f1b6b13df344daebd3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8ec4a34afd1345f1b6b13df344daebd3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8ec4a34afd1345f1b6b13df344daebd32021-12-02T06:45:45ZWhat are the links between hypoxia and Alzheimer’s disease?1178-2021https://doaj.org/article/8ec4a34afd1345f1b6b13df344daebd32019-05-01T00:00:00Zhttps://www.dovepress.com/what-are-the-links-between-hypoxia-and-alzheimers-disease-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Rahul Lall,1 Raihan Mohammed,1 Utkarsh Ojha21Department of Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine, Imperial College London, London, UKAbstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease. Histological characterization of amyloid plaques and neurofibrillary tangles in the brains of AD patients, alongside genetic studies in individuals suffering the familial form of the disease, has fueled the accumulation of the amyloid-β protein as the initial pathological trigger of disease. Association studies have recently showed that cerebral hypoxia, via both genetic and epigenetic mechanisms, increase amyloid-β deposition by altering expression levels of enzymes involved in the production/degradation of the protein. Furthermore, hypoxia has also been linked to neuronal and glial-cell calcium dysregulation through formation of calcium-permeable pores, dysregulated glutamate signaling, and intracellular calcium-store dysfunction. Hypoxia has also been strongly linked to neuroinflammation; however, this relationship to AD has not been thoroughly discussed in the literature. Here, we highlight and organize critical research evidence showing that in both hypoxic and AD brains, there are similarities in terms of 1) the substances mediating/modulating the neuroinflammatory environment and 2) the immune cells that drive the formation of these substances.Keywords: hypoxia, AB accumulation, amyloid, calcium, neuroinflammation, ischemiaLall RMohammed ROjha UDove Medical PressarticleHypoxiaAB accumulationamyloidcalciumneuroinflammationmicrogliaischaemiaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1343-1354 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Hypoxia AB accumulation amyloid calcium neuroinflammation microglia ischaemia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Hypoxia AB accumulation amyloid calcium neuroinflammation microglia ischaemia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lall R Mohammed R Ojha U What are the links between hypoxia and Alzheimer’s disease? |
| description |
Rahul Lall,1 Raihan Mohammed,1 Utkarsh Ojha21Department of Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine, Imperial College London, London, UKAbstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease. Histological characterization of amyloid plaques and neurofibrillary tangles in the brains of AD patients, alongside genetic studies in individuals suffering the familial form of the disease, has fueled the accumulation of the amyloid-β protein as the initial pathological trigger of disease. Association studies have recently showed that cerebral hypoxia, via both genetic and epigenetic mechanisms, increase amyloid-β deposition by altering expression levels of enzymes involved in the production/degradation of the protein. Furthermore, hypoxia has also been linked to neuronal and glial-cell calcium dysregulation through formation of calcium-permeable pores, dysregulated glutamate signaling, and intracellular calcium-store dysfunction. Hypoxia has also been strongly linked to neuroinflammation; however, this relationship to AD has not been thoroughly discussed in the literature. Here, we highlight and organize critical research evidence showing that in both hypoxic and AD brains, there are similarities in terms of 1) the substances mediating/modulating the neuroinflammatory environment and 2) the immune cells that drive the formation of these substances.Keywords: hypoxia, AB accumulation, amyloid, calcium, neuroinflammation, ischemia |
| format |
article |
| author |
Lall R Mohammed R Ojha U |
| author_facet |
Lall R Mohammed R Ojha U |
| author_sort |
Lall R |
| title |
What are the links between hypoxia and Alzheimer’s disease? |
| title_short |
What are the links between hypoxia and Alzheimer’s disease? |
| title_full |
What are the links between hypoxia and Alzheimer’s disease? |
| title_fullStr |
What are the links between hypoxia and Alzheimer’s disease? |
| title_full_unstemmed |
What are the links between hypoxia and Alzheimer’s disease? |
| title_sort |
what are the links between hypoxia and alzheimer’s disease? |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/8ec4a34afd1345f1b6b13df344daebd3 |
| work_keys_str_mv |
AT lallr whatarethelinksbetweenhypoxiaandalzheimerrsquosdisease AT mohammedr whatarethelinksbetweenhypoxiaandalzheimerrsquosdisease AT ojhau whatarethelinksbetweenhypoxiaandalzheimerrsquosdisease |
| _version_ |
1718399764962213888 |