GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY

Abstract. Galectins comprise a family of β-galactoside-binding animal proteins, which are defined bycommon homologies of their carbohydrate-recognizing domaine (affinity for poly-N-acetyllactosamine). These lectins bind to cell surface glycans and extracellular matrix, thus influencing various cellu...

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Autores principales:	V. D. Yakushina, O. A. Vasilyeva, N. V. Ryazantseva, V. V. Novitsky, O. E. Savelyeva, T. S. Prokhorenko, E. G. Starikova, A. P. Zima
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	galectin-1 immunity, apoptosis th lymphocyte differentiation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8ec4a611aaa14c8a8f3273c8bd9d3a03
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spelling	oai:doaj.org-article:8ec4a611aaa14c8a8f3273c8bd9d3a032021-11-18T08:03:39ZGALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY1563-06252313-741X10.15789/1563-0625-2012-1-2-21-32https://doaj.org/article/8ec4a611aaa14c8a8f3273c8bd9d3a032014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/288https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Galectins comprise a family of β-galactoside-binding animal proteins, which are defined bycommon homologies of their carbohydrate-recognizing domaine (affinity for poly-N-acetyllactosamine). These lectins bind to cell surface glycans and extracellular matrix, thus influencing various cellular events, including cell cycle, adhesion, migration, proliferation and apoptosis. Moreover, galectins are able to exert intracellular effects, and participate, e.g., in signal transduction, by interacting with other nuclear and cytoplasmic proteins. Galectin-1 is considered to play a special role in functional regulation of immune cell activity. Thus protein is a factor of immunocompetent cell cooperation, thus being able to modulate immune reactions. In this respect, galectin-1 is considered as a potential agent or a target for new methods aimed to correct pathological processes associated with imbalance of immune system. This article provides an overview of works devoted to a possible role of galectin-1 in development of typical features of innate and adaptive immunity.V. D. YakushinaO. A. VasilyevaN. V. RyazantsevaV. V. NovitskyO. E. SavelyevaT. S. ProkhorenkoE. G. StarikovaA. P. ZimaSPb RAACIarticlegalectin-1immunity, apoptosisth lymphocyte differentiationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 21-32 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	galectin-1 immunity, apoptosis th lymphocyte differentiation Immunologic diseases. Allergy RC581-607
spellingShingle	galectin-1 immunity, apoptosis th lymphocyte differentiation Immunologic diseases. Allergy RC581-607 V. D. Yakushina O. A. Vasilyeva N. V. Ryazantseva V. V. Novitsky O. E. Savelyeva T. S. Prokhorenko E. G. Starikova A. P. Zima GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY
description	Abstract. Galectins comprise a family of β-galactoside-binding animal proteins, which are defined bycommon homologies of their carbohydrate-recognizing domaine (affinity for poly-N-acetyllactosamine). These lectins bind to cell surface glycans and extracellular matrix, thus influencing various cellular events, including cell cycle, adhesion, migration, proliferation and apoptosis. Moreover, galectins are able to exert intracellular effects, and participate, e.g., in signal transduction, by interacting with other nuclear and cytoplasmic proteins. Galectin-1 is considered to play a special role in functional regulation of immune cell activity. Thus protein is a factor of immunocompetent cell cooperation, thus being able to modulate immune reactions. In this respect, galectin-1 is considered as a potential agent or a target for new methods aimed to correct pathological processes associated with imbalance of immune system. This article provides an overview of works devoted to a possible role of galectin-1 in development of typical features of innate and adaptive immunity.
format	article
author	V. D. Yakushina O. A. Vasilyeva N. V. Ryazantseva V. V. Novitsky O. E. Savelyeva T. S. Prokhorenko E. G. Starikova A. P. Zima
author_facet	V. D. Yakushina O. A. Vasilyeva N. V. Ryazantseva V. V. Novitsky O. E. Savelyeva T. S. Prokhorenko E. G. Starikova A. P. Zima
author_sort	V. D. Yakushina
title	GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY
title_short	GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY
title_full	GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY
title_fullStr	GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY
title_full_unstemmed	GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY
title_sort	galectin-1 and its role in development of innate and adaptive immunity
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8ec4a611aaa14c8a8f3273c8bd9d3a03
work_keys_str_mv	AT vdyakushina galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT oavasilyeva galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT nvryazantseva galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT vvnovitsky galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT oesavelyeva galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT tsprokhorenko galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT egstarikova galectin1anditsroleindevelopmentofinnateandadaptiveimmunity AT apzima galectin1anditsroleindevelopmentofinnateandadaptiveimmunity
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GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY

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