New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets

Abstract The communication between endoplasmic reticulum (ER) and mitochondria (Mt) plays important roles in maintenance of intra‐ and extra‐cellular microenvironment, metabolisms, signaling activities and cell‐cell communication. The present review aims to overview the advanced understanding about...

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Autores principales:	Linlin Zhang, Furong Yan, Liyang Li, Huirong Fu, Dongli Song, Duojiao Wu, Xiangdong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	communications contacts diseases endoplasmic reticulum homeostasis mitochondria Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8ec4d37901b64c38b26b6bf7f44c7800
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spelling	oai:doaj.org-article:8ec4d37901b64c38b26b6bf7f44c78002021-11-30T07:25:37ZNew focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets2001-132610.1002/ctm2.626https://doaj.org/article/8ec4d37901b64c38b26b6bf7f44c78002021-11-01T00:00:00Zhttps://doi.org/10.1002/ctm2.626https://doaj.org/toc/2001-1326Abstract The communication between endoplasmic reticulum (ER) and mitochondria (Mt) plays important roles in maintenance of intra‐ and extra‐cellular microenvironment, metabolisms, signaling activities and cell‐cell communication. The present review aims to overview the advanced understanding about roles of ER‐Mt structural contacts, molecular interactions and chemical exchanges, signal transmissions and inter‐organelle regulations in ER‐Mt communication. We address how the ER‐Mt communication contributes to the regulation of lipid, amino acid and glucose metabolisms by enzymes, transporters and regulators in the process of biosynthesis. We specially emphasize the importance of deep understanding about molecular mechanisms of ER‐Mt communication for identification and development of biology‐specific, disease‐specific and metabolism‐specific biomarkers and therapeutic targets for human diseases. The inhibitors and modulators of the ER‐Mt communication are categorized according to therapeutic targets. Rapid development of biotechnologies will provide new insights for spatiotemporally understanding the molecular mechanisms of ER‐Mt communication.Linlin ZhangFurong YanLiyang LiHuirong FuDongli SongDuojiao WuXiangdong WangWileyarticlecommunicationscontactsdiseasesendoplasmic reticulumhomeostasismitochondriaMedicine (General)R5-920ENClinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	communications contacts diseases endoplasmic reticulum homeostasis mitochondria Medicine (General) R5-920
spellingShingle	communications contacts diseases endoplasmic reticulum homeostasis mitochondria Medicine (General) R5-920 Linlin Zhang Furong Yan Liyang Li Huirong Fu Dongli Song Duojiao Wu Xiangdong Wang New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
description	Abstract The communication between endoplasmic reticulum (ER) and mitochondria (Mt) plays important roles in maintenance of intra‐ and extra‐cellular microenvironment, metabolisms, signaling activities and cell‐cell communication. The present review aims to overview the advanced understanding about roles of ER‐Mt structural contacts, molecular interactions and chemical exchanges, signal transmissions and inter‐organelle regulations in ER‐Mt communication. We address how the ER‐Mt communication contributes to the regulation of lipid, amino acid and glucose metabolisms by enzymes, transporters and regulators in the process of biosynthesis. We specially emphasize the importance of deep understanding about molecular mechanisms of ER‐Mt communication for identification and development of biology‐specific, disease‐specific and metabolism‐specific biomarkers and therapeutic targets for human diseases. The inhibitors and modulators of the ER‐Mt communication are categorized according to therapeutic targets. Rapid development of biotechnologies will provide new insights for spatiotemporally understanding the molecular mechanisms of ER‐Mt communication.
format	article
author	Linlin Zhang Furong Yan Liyang Li Huirong Fu Dongli Song Duojiao Wu Xiangdong Wang
author_facet	Linlin Zhang Furong Yan Liyang Li Huirong Fu Dongli Song Duojiao Wu Xiangdong Wang
author_sort	Linlin Zhang
title	New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
title_short	New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
title_full	New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
title_fullStr	New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
title_full_unstemmed	New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
title_sort	new focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/8ec4d37901b64c38b26b6bf7f44c7800
work_keys_str_mv	AT linlinzhang newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets AT furongyan newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets AT liyangli newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets AT huirongfu newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets AT donglisong newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets AT duojiaowu newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets AT xiangdongwang newfocusesonrolesofcommunicationsbetweenendoplasmicreticulumandmitochondriainidentificationofbiomarkersandtargets
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New focuses on roles of communications between endoplasmic reticulum and mitochondria in identification of biomarkers and targets

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