Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence

Shasha Li,1,2 Ana Luiza Zaninotto,2,3 Iuri Santana Neville,4 Wellingson Silva Paiva,4 Danuza Nunn,2 Felipe Fregni21Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Spaulding Neuromodulation Center, Harvard Medica...

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Autores principales:	Li S, Zaninotto AL, Neville IS, Paiva WS, Nunn D, Fregni F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8ecb5a56a8794bf6aad6a1ede70a141a
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spelling	oai:doaj.org-article:8ecb5a56a8794bf6aad6a1ede70a141a2021-12-02T03:35:45ZClinical utility of brain stimulation modalities following traumatic brain injury: current evidence1178-2021https://doaj.org/article/8ecb5a56a8794bf6aad6a1ede70a141a2015-06-01T00:00:00Zhttp://www.dovepress.com/clinical-utility-of-brain-stimulation-modalities-following-traumatic-b-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shasha Li,1,2 Ana Luiza Zaninotto,2,3 Iuri Santana Neville,4 Wellingson Silva Paiva,4 Danuza Nunn,2 Felipe Fregni21Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Spaulding Neuromodulation Center, Harvard Medical School, Boston, MA, USA; 3Division of Psychology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil; 4Division of Neurosurgery, University of São Paulo Medical School, São Paulo, São Paulo, BrazilAbstract: Traumatic brain injury (TBI) remains the main cause of disability and a major public health problem worldwide. This review focuses on the neurophysiology of TBI, and the rationale and current state of evidence of clinical application of brain stimulation to promote TBI recovery, particularly on consciousness, cognitive function, motor impairments, and psychiatric conditions. We discuss the mechanisms of different brain stimulation techniques including major noninvasive and invasive stimulations. Thus far, most noninvasive brain stimulation interventions have been nontargeted and focused on the chronic phase of recovery after TBI. In the acute stages, there is limited available evidence of the efficacy and safety of brain stimulation to improve functional outcomes. Comparing the studies across different techniques, transcranial direct current stimulation is the intervention that currently has the higher number of properly designed clinical trials, though total number is still small. We recognize the need for larger studies with target neuroplasticity modulation to fully explore the benefits of brain stimulation to effect TBI recovery during different stages of recovery.Keywords: traumatic brain injury, brain stimulation, neuroplasticityLi SZaninotto ALNeville ISPaiva WSNunn DFregni FDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1573-1586 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li S Zaninotto AL Neville IS Paiva WS Nunn D Fregni F Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
description	Shasha Li,1,2 Ana Luiza Zaninotto,2,3 Iuri Santana Neville,4 Wellingson Silva Paiva,4 Danuza Nunn,2 Felipe Fregni21Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Spaulding Neuromodulation Center, Harvard Medical School, Boston, MA, USA; 3Division of Psychology, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil; 4Division of Neurosurgery, University of São Paulo Medical School, São Paulo, São Paulo, BrazilAbstract: Traumatic brain injury (TBI) remains the main cause of disability and a major public health problem worldwide. This review focuses on the neurophysiology of TBI, and the rationale and current state of evidence of clinical application of brain stimulation to promote TBI recovery, particularly on consciousness, cognitive function, motor impairments, and psychiatric conditions. We discuss the mechanisms of different brain stimulation techniques including major noninvasive and invasive stimulations. Thus far, most noninvasive brain stimulation interventions have been nontargeted and focused on the chronic phase of recovery after TBI. In the acute stages, there is limited available evidence of the efficacy and safety of brain stimulation to improve functional outcomes. Comparing the studies across different techniques, transcranial direct current stimulation is the intervention that currently has the higher number of properly designed clinical trials, though total number is still small. We recognize the need for larger studies with target neuroplasticity modulation to fully explore the benefits of brain stimulation to effect TBI recovery during different stages of recovery.Keywords: traumatic brain injury, brain stimulation, neuroplasticity
format	article
author	Li S Zaninotto AL Neville IS Paiva WS Nunn D Fregni F
author_facet	Li S Zaninotto AL Neville IS Paiva WS Nunn D Fregni F
author_sort	Li S
title	Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
title_short	Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
title_full	Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
title_fullStr	Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
title_full_unstemmed	Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
title_sort	clinical utility of brain stimulation modalities following traumatic brain injury: current evidence
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8ecb5a56a8794bf6aad6a1ede70a141a
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Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence

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