Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB

In recent months, the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis with takeover more than 1 million lives worldwide. The long-lasting existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not yet been reported. Herein, we report...

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Autores principales:	Li Wenyuan, Huang Beibei, Shen Qiang, Jiang Shouwei, Jin Kun, Ning Ling, Liu Lei, Li Lei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	covid-19 sars-cov-2 convalescence coronavirus case report Medicine R
Acceso en línea:	https://doaj.org/article/8ece37f7a0274aa893d3bd961bcbed90
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spelling	oai:doaj.org-article:8ece37f7a0274aa893d3bd961bcbed902021-12-05T14:10:54ZPersistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB2391-546310.1515/med-2021-0283https://doaj.org/article/8ece37f7a0274aa893d3bd961bcbed902021-05-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0283https://doaj.org/toc/2391-5463In recent months, the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis with takeover more than 1 million lives worldwide. The long-lasting existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not yet been reported. Herein, we report a case of SARS-CoV-2 infection with intermittent viral polymerase chain reaction (PCR)-positive for >4 months after clinical rehabilitation. A 35-year-old male was diagnosed with COVID-19 pneumonia with fever but without other specific symptoms. The treatment with lopinavir-ritonavir, oxygen inhalation, and other symptomatic supportive treatment facilitated recovery, and the patient was discharged. However, his viral PCR test was continually positive in oropharyngeal swabs for >4 months after that. At the end of June 2020, he was still under quarantine and observation. The contribution of current antivirus therapy might be limited. The prognosis of COVID-19 patients might be irrelevant to the virus status. Thus, further investigation to evaluate the contagiousness of convalescent patients and the mechanism underlying the persistent existence of SARS-CoV-2 after recovery is essential. A new strategy of disease control, especially extending the follow-up period for recovered COVID-19 patients, is necessary to adapt to the current situation of pandemic.Li WenyuanHuang BeibeiShen QiangJiang ShouweiJin KunNing LingLiu LeiLi LeiDe Gruyterarticlecovid-19sars-cov-2convalescencecoronaviruscase reportMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 749-753 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 sars-cov-2 convalescence coronavirus case report Medicine R
spellingShingle	covid-19 sars-cov-2 convalescence coronavirus case report Medicine R Li Wenyuan Huang Beibei Shen Qiang Jiang Shouwei Jin Kun Ning Ling Liu Lei Li Lei Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
description	In recent months, the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis with takeover more than 1 million lives worldwide. The long-lasting existence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not yet been reported. Herein, we report a case of SARS-CoV-2 infection with intermittent viral polymerase chain reaction (PCR)-positive for >4 months after clinical rehabilitation. A 35-year-old male was diagnosed with COVID-19 pneumonia with fever but without other specific symptoms. The treatment with lopinavir-ritonavir, oxygen inhalation, and other symptomatic supportive treatment facilitated recovery, and the patient was discharged. However, his viral PCR test was continually positive in oropharyngeal swabs for >4 months after that. At the end of June 2020, he was still under quarantine and observation. The contribution of current antivirus therapy might be limited. The prognosis of COVID-19 patients might be irrelevant to the virus status. Thus, further investigation to evaluate the contagiousness of convalescent patients and the mechanism underlying the persistent existence of SARS-CoV-2 after recovery is essential. A new strategy of disease control, especially extending the follow-up period for recovered COVID-19 patients, is necessary to adapt to the current situation of pandemic.
format	article
author	Li Wenyuan Huang Beibei Shen Qiang Jiang Shouwei Jin Kun Ning Ling Liu Lei Li Lei
author_facet	Li Wenyuan Huang Beibei Shen Qiang Jiang Shouwei Jin Kun Ning Ling Liu Lei Li Lei
author_sort	Li Wenyuan
title	Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
title_short	Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
title_full	Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
title_fullStr	Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
title_full_unstemmed	Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB
title_sort	persistent sars-cov-2-positive over 4 months in a covid-19 patient with chb
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/8ece37f7a0274aa893d3bd961bcbed90
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Persistent SARS-CoV-2-positive over 4 months in a COVID-19 patient with CHB

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