CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL

Objective: To correlate different cytomorphological presentations of cervical lymphadenitis suspected for Myco-bacterium Tuberculosis (MTB) on Fine Needle Aspiration Cytology (FNAC) with Mycobacterium Tuberculosis detection by geneXpert on aspirated material. Study Design: Comparative, cross sect...

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Autores principales:	Hamza Mansur, Muhammad Asif, Muhammad Tahir Khadim, Iqbal Muhammad Khan, Rabia Ahmad, Anza Azhar, Madeeha Anwar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	cervical lymphadenitis cytomorphological patterns fine needle aspiration Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8eceaa214e3a4fb69fba7b8f9e02a809
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spelling	oai:doaj.org-article:8eceaa214e3a4fb69fba7b8f9e02a8092021-11-05T04:10:32ZCONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL0030-96482411-8842https://doaj.org/article/8eceaa214e3a4fb69fba7b8f9e02a8092019-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3628/2451https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To correlate different cytomorphological presentations of cervical lymphadenitis suspected for Myco-bacterium Tuberculosis (MTB) on Fine Needle Aspiration Cytology (FNAC) with Mycobacterium Tuberculosis detection by geneXpert on aspirated material. Study Design: Comparative, cross sectional study. Place and Duration of Study: Department of Histopathology, Armed Forces Institute of Pathology Rawalpindi, Jan 2017 to Nov 2018. Methodology: Fine needle aspirates of total 100 patients with cervical lymphadenitis suspected for Mycobac-terium Tuberculosis were included and the cytomorphology was compared with geneXpert. Data was analyzed using SPSS version 23. Results: A total of 100 cases were included. A total of 78 cases were positive for Mycobacterium Tuberculosis while 22 cases were negative when compared with molecular analysis on aspirated material. Positivity for Mycobacterium Tuberculosis by geneXpert was seen in 93% of cases with both caseous necrosis and granulomas, 80% of cases with caseous necrosis only, 80% of cases having granulomas along with neutrophilic abscess, 70% of cases showing granulomas and 14% of cases with neutrophilic abscess (p-value<0.05). Sensitivity of Fine Needle Aspiration Cytology was 97% and specificity was 54%. Positive Predictive Value was 88% and Negative Predictive Value was 85%. Conclusion: Mycobacterium Tuberculosis was detected by GeneXpert in a significant percentage of the Fine Needle Aspiration Cytology samples included in our study. Fine Needle Aspiration Cytology is a rapid, safe, easily available, minimally invasive, outpatient procedure and GeneXpert analysis can be performed on the aspirated material.Hamza MansurMuhammad AsifMuhammad Tahir KhadimIqbal Muhammad KhanRabia AhmadAnza AzharMadeeha AnwarArmy Medical College Rawalpindiarticlecervical lymphadenitiscytomorphological patternsfine needle aspirationMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 6, Pp 1173-1178 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical lymphadenitis cytomorphological patterns fine needle aspiration Medicine R Medicine (General) R5-920
spellingShingle	cervical lymphadenitis cytomorphological patterns fine needle aspiration Medicine R Medicine (General) R5-920 Hamza Mansur Muhammad Asif Muhammad Tahir Khadim Iqbal Muhammad Khan Rabia Ahmad Anza Azhar Madeeha Anwar CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL
description	Objective: To correlate different cytomorphological presentations of cervical lymphadenitis suspected for Myco-bacterium Tuberculosis (MTB) on Fine Needle Aspiration Cytology (FNAC) with Mycobacterium Tuberculosis detection by geneXpert on aspirated material. Study Design: Comparative, cross sectional study. Place and Duration of Study: Department of Histopathology, Armed Forces Institute of Pathology Rawalpindi, Jan 2017 to Nov 2018. Methodology: Fine needle aspirates of total 100 patients with cervical lymphadenitis suspected for Mycobac-terium Tuberculosis were included and the cytomorphology was compared with geneXpert. Data was analyzed using SPSS version 23. Results: A total of 100 cases were included. A total of 78 cases were positive for Mycobacterium Tuberculosis while 22 cases were negative when compared with molecular analysis on aspirated material. Positivity for Mycobacterium Tuberculosis by geneXpert was seen in 93% of cases with both caseous necrosis and granulomas, 80% of cases with caseous necrosis only, 80% of cases having granulomas along with neutrophilic abscess, 70% of cases showing granulomas and 14% of cases with neutrophilic abscess (p-value<0.05). Sensitivity of Fine Needle Aspiration Cytology was 97% and specificity was 54%. Positive Predictive Value was 88% and Negative Predictive Value was 85%. Conclusion: Mycobacterium Tuberculosis was detected by GeneXpert in a significant percentage of the Fine Needle Aspiration Cytology samples included in our study. Fine Needle Aspiration Cytology is a rapid, safe, easily available, minimally invasive, outpatient procedure and GeneXpert analysis can be performed on the aspirated material.
format	article
author	Hamza Mansur Muhammad Asif Muhammad Tahir Khadim Iqbal Muhammad Khan Rabia Ahmad Anza Azhar Madeeha Anwar
author_facet	Hamza Mansur Muhammad Asif Muhammad Tahir Khadim Iqbal Muhammad Khan Rabia Ahmad Anza Azhar Madeeha Anwar
author_sort	Hamza Mansur
title	CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL
title_short	CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL
title_full	CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL
title_fullStr	CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL
title_full_unstemmed	CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL
title_sort	concordance of cytomorphoolgical features of cervical lymphadenitis suspected for mycobacterium tuberculosis on fine needle aspiration biopsy with genexpert for mycobacterium tuberculosis on aspirated material
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/8eceaa214e3a4fb69fba7b8f9e02a809
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CONCORDANCE OF CYTOMORPHOOLGICAL FEATURES OF CERVICAL LYMPHADENITIS SUSPECTED FOR MYCOBACTERIUM TUBERCULOSIS ON FINE NEEDLE ASPIRATION BIOPSY WITH GENEXPERT FOR MYCOBACTERIUM TUBERCULOSIS ON ASPIRATED MATERIAL

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