INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS

Intravenous immunoglobulins (IVIG) are currently the most widely used immunobiological drug derived from donor blood. The IVIG preparations contain antibodies, mostly, of IgG class, obtained from plasma pools of 3,000 to 15,000 donors (over 1000 donors per lot, according to international standards a...

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Autores principales:	V. A. Lazanovich, E. V. Prosekova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	intravenous immunoglobulin therapy mechanism Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8ed4342c9bdc4d5fa4a83c4ced64c76c
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spelling	oai:doaj.org-article:8ed4342c9bdc4d5fa4a83c4ced64c76c2021-11-18T08:03:43ZINTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS1563-06252313-741X10.15789/1563-0625-2014-4-311-322https://doaj.org/article/8ed4342c9bdc4d5fa4a83c4ced64c76c2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/697https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIntravenous immunoglobulins (IVIG) are currently the most widely used immunobiological drug derived from donor blood. The IVIG preparations contain antibodies, mostly, of IgG class, obtained from plasma pools of 3,000 to 15,000 donors (over 1000 donors per lot, according to international standards and guidelines), being used for treatment of various diseases over four last decades. Initially, IVIG application wasaimed for immune support only in primary immunodeficiency states. However, recent clinical and experimental data show effectiveness of the IVIG in systemic and autoimmune diseases, immune-associated infertility and miscarriage. As well as in translantology, hematology and other fields of medicine. Their efficiency is associated with immunomodulatory effects. There is a growing number of publications bearing on this subject and elucidating possible mechanisms of therapeutic effects of IVIG, which are based on the latest basic and clinical research findings in this area. At the same time, much issues remain unclear and contradictory, and some data are mutually exclusive, thus prompting further studies and trials of IVIG preparations. The aim of this article is to summarize the known basic mechanisms of therapeutic effects, main results of recent research in this area,and potential clinical applications of IVIG in future.V. A. LazanovichE. V. ProsekovaSPb RAACIarticleintravenous immunoglobulintherapymechanismImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 311-322 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	intravenous immunoglobulin therapy mechanism Immunologic diseases. Allergy RC581-607
spellingShingle	intravenous immunoglobulin therapy mechanism Immunologic diseases. Allergy RC581-607 V. A. Lazanovich E. V. Prosekova INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS
description	Intravenous immunoglobulins (IVIG) are currently the most widely used immunobiological drug derived from donor blood. The IVIG preparations contain antibodies, mostly, of IgG class, obtained from plasma pools of 3,000 to 15,000 donors (over 1000 donors per lot, according to international standards and guidelines), being used for treatment of various diseases over four last decades. Initially, IVIG application wasaimed for immune support only in primary immunodeficiency states. However, recent clinical and experimental data show effectiveness of the IVIG in systemic and autoimmune diseases, immune-associated infertility and miscarriage. As well as in translantology, hematology and other fields of medicine. Their efficiency is associated with immunomodulatory effects. There is a growing number of publications bearing on this subject and elucidating possible mechanisms of therapeutic effects of IVIG, which are based on the latest basic and clinical research findings in this area. At the same time, much issues remain unclear and contradictory, and some data are mutually exclusive, thus prompting further studies and trials of IVIG preparations. The aim of this article is to summarize the known basic mechanisms of therapeutic effects, main results of recent research in this area,and potential clinical applications of IVIG in future.
format	article
author	V. A. Lazanovich E. V. Prosekova
author_facet	V. A. Lazanovich E. V. Prosekova
author_sort	V. A. Lazanovich
title	INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS
title_short	INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS
title_full	INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS
title_fullStr	INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS
title_full_unstemmed	INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS
title_sort	intravenous immunoglobulins: mechanisms of therapeutic effects
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8ed4342c9bdc4d5fa4a83c4ced64c76c
work_keys_str_mv	AT valazanovich intravenousimmunoglobulinsmechanismsoftherapeuticeffects AT evprosekova intravenousimmunoglobulinsmechanismsoftherapeuticeffects
_version_	1718422434161360896

INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS

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